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TranscriptomicsKinetoplastid-specific histone variant functions are conserved in Leishmania major
Protein-coding genes in kinetoplastid protists are transcribed from polycistronic arrays, yielding RNA precursors which are processed to form mature transcripts bearing a 5M-bM-^@M-^Y spliced leader (SL) and 3M-bM-^@M-^Y poly(A) tract. Regions of transcription initiation and termination lack known e...
ORGANISM(S): Leishmania major 
2013-10-26 | E-GEOD-51737 | biostudies-arrayexpress
TranscriptomicsExpression profiling in extracellular miRNAs (plasma miRNAs) of CML patients after imatinib discontinuation (STOP-IM)
An approximately 40% of chronic myeloid leukemia (CML) patients who discontinued imatinib (IM) therapy maintained undetectable minimal residual disease (UMRD) for more than one year (STOP-IM). We set out to examine plasma miRNAs expression in CML patients who could discontinue IM, to seek the possib...
ORGANISM(S): Homo sapiens 
2016-03-31 | E-GEOD-75391 | biostudies-arrayexpress
TranscriptomicsDynamics of two oscillation phenotypes in S. cerevisiae reveal a network of genome-wide transcriptional and cell cycle oscillators.
This SuperSeries is composed of the following subset Series: GSE30051: Dynamics of two oscillation phenotypes in S. cerevisiae[2hr] GSE30052: Dynamics of two oscillation phenotypes in S. cerevisiae[4hr]. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-16 | E-GEOD-30053 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human patient-derived xenograft pancreatic cancer PancA6L cells cultured for 14 days with Galactose versus PancA6L cells cultured for 14 days with Glucose
The goal of the study was to identify genes and pathways that were altered when human pancreatic ductal adenocarcinoma (PDAC) cancer cells are cultured with different carbon source (Glucose versus Galactose). Primary adherent cultures established from patient-derived xenograft passaged in mice were...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9483 | biostudies-arrayexpress
ProteomicsVincristine resistance reshapes sphingolipid composition and promotes mitochondrial complex I deficiency in acute myelogenous leukemia
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer treatment, are no exception, as their beneficial actio...
ORGANISM(S): Homo Sapiens (human) 
2022-04-21 | PXD025645 | JPOST Repository
TranscriptomicsIntestinal Salmonella Typhimurium infection leads to miR-29a induced Caveolin 2 regulation [mRNA]
The host response to S.typhimurium infections in ileum was studied after infection of piglets. mRNA and miRNA expression studies were performed to identify interactions of miRNAs and regulated mRNAs in context of mammalian intestinal Salmonella infection using a piglet model. Intestinal samples (~ 2...
ORGANISM(S): Sus scrofa 
2013-06-25 | E-GEOD-40804 | biostudies-arrayexpress
TranscriptomicsMycorrhizal Metabolome: L. bicolor :: P. trichocapra
Mycorrhizae, symbiotic interactions between soil fungi and tree roots, are ubiquitous in terrestrial ecosystems. The fungi contribute phosphorous, nitrogen and mobilized nutrients from organic matter in the soil and in return the fungus receives photosynthetically-derived carbohydrates. This union...
ORGANISM(S): Populus tremuloides 
2011-03-25 | E-GEOD-28157 | biostudies-arrayexpress
TranscriptomicsMicroRNA-offset RNA regulates gene expression and cell proliferation (Small RNA-Seq)
MicroRNA-offset RNAs (moRs) were first identified in simple chordates and subsequently in mouse and human cells by deep sequencing of short RNAs. MoRs are derived from sequences located immediately adjacent to microRNAs (miRs) in the primary miR (pri-miR). Currently moRs are considered to be simply ...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-75113 | biostudies-arrayexpress
TranscriptomicsAn arginine sensing pathway in Leishmania induces a Mitogen-Activated Protein Kinase 2-mediated response during macrophage invasion
Protozoa of the genus Leishmania are the causative agents of leishmaniasis in humans. These parasites cycle between promastigotes in the sand fly mid-gut and amastigotes in phagolysosome of mammalian macrophages. During infection, host up-regulate nitric oxide synthase and parasite induce host argin...
ORGANISM(S): Leishmania donovani 
2016-08-01 | E-GEOD-71572 | biostudies-arrayexpress
TranscriptomicsGenetic Influences on Asthma Susceptibility in Developing Lung
Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14). Total RNA obtained from whole lung of rat from 3 genetic strains and 3 postnatal time points in (mainly) quadruplicate measurements per strain and...
ORGANISM(S): Rattus norvegicus 
2010-06-24 | E-GEOD-19666 | biostudies-arrayexpress
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