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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
MetabolomicsIntracellular iron overload rewires HSC metabolism by impairing mitochondrial fitness
Iron is an essential element for several cellular processes and recent evidence highlighted its role in regulating the function of hematopoietic stem cells (HSCs). When in excess it reduces quiescence and self-renewal, however, whether and how iron influences HSC metabolism is still unknown. Here, w...
2024-12-04 | MTBLS11778 | MetaboLights
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
PXD054574 |
ProteomicsTargeting the fitness cost of antibiotic resistance via the non-essential genome
Mutations in the rifampicin (Rif)-binding site of RNA polymerase (RNAP) impart antibiotic resistance and inextricably affect transcription initiation, elongation, and termination properties as well. At each step of the transcription cycle, RNAP responds to non-essential transcription factors, signal...
ORGANISM(S): Escherichia coli 
2021-11-25 | PXD027810 | Pride
Fitness cost Antibiotic resistance Rifampicin Rna polymerase 
TranscriptomicsIdentifying the fitness cost of rifampicin-resistance in Mycobacterium tuberculosis through RNAseq profiling.
The experiment was designed to infer the fitness cost of rifampicin-resistance in Mycobacterium tuberculosis through expression analysis. The approach relied on: 1. Tracking the expression changes occurring as a result of the rifampicin-resistance conferring mutation Ser450Leu in RpoB and subsequent...
ORGANISM(S): Mycobacterium tuberculosis 
2018-11-18 | E-MTAB-7359 | biostudies-arrayexpress
ProteomicsThe fitness cost of spurious phosphorylation
The fidelity of signal transmission requires the binding of regulatory molecules to their cognate targets. However, the crowded cell interior risks off-target interactions between proteins that are functionally unrelated. Understanding the constraints this imposes on cell systems evolution requires ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-09-12 | PXD045466 | Pride
Spurious Human Lcms Phosphotyrosine Yeast 
TranscriptomicsImmunogenic males: a genome-wide analysis of reproduction and the cost of mating in Drosophila melanogaster females
In Drosophila melanogaster, mating radically transforms female physiology and behavior. Post-mating responses include an increase in the oviposition rate, a reduction in female receptivity, and an activation of the immune system . The fitness consequences of mating are similarly dramatic – females m...
ORGANISM(S): Drosophila melanogaster 
2009-02-18 | E-GEOD-12834 | biostudies-arrayexpress
ProteomicsIn vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
Sulfonamides are traditional synthetic antimicrobial agents used in clinical and veterinary medical settings. Their long-term excessive overuse has resulted in widespread microbial resistance, limiting their application for medical interventions. Resistance to sulfonamides is primarily conferred by ...
ORGANISM(S): Escherichia Coli Str. K-12 Substr. Mg1655 
PXD053633 |
GenomicsIdentifying the fitness cost of rifampicin-resistance in Mycobacterium tuberculosis through RNAseq profiling.
Identifying the fitness cost of rifampicin-resistance in Mycobacterium tuberculosis through RNAseq profiling.
PRJEB29591 | ENA
GenomicsDissemination of IncI plasmid encoding blaCTX-M-1 is not hampered by its fitness cost in the pig’s gut.
Fitness cost of blaCTX-M-1 IncI1/ST3 plasmids in E. coli
PRJEB58070 | ENA
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