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ProteomicsLarge-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins using SILAC-SPROX
Proteomic methods for disease state characterization and biomarker discovery have traditionally utilized quantitative mass spectrometry methods to identify proteins with altered expression levels in disease states. Here we report on the large-scale use of protein folding stability measurements to ch...
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD006703 | Pride
Mcf-7 Chemical denaturation Bt-474 Mda-mb-468 Protein folding 
ProteomicsManassantin A SILAC-Pulse Proteolysis
Manassantin A is a natural product that has been isolated from the perennial herb Saururus chinensis Baill and the aquatic plant Saururus cernuus. Manassantin A has been shown to possess potent hypoxia inducible factor 1 alpha (HIF-1α) inhibitory activity in a cell-based assay screen of thousands o...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD002305 | Pride
Drug mode-of-action In-gel digestion Mda-mb-231 Pulse proteolysis Stable isotope labeling of amino acids in cell culture Manassantin a 
ProteomicsProteome-Wide Characterization of Phosphorylation-Induced Conformational and Stability Changes in Breast Cancer
Large-scale studies of protein phosphorylation have generally focused on determining the sites and stoichiometry of phosphorylated proteins derived from different biological specimens such as cell lines and tissue samples. While such information is important for understanding the role of phosphoryla...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD007916 | Pride
Protein stability Phosphorylation Human breast cancer Protein conformation 
ProteomicsLarge-Scale Characterization of Phosphorylation-Induced Conformational and Stability Changes in Breast Cancer
Large-scale studies of protein phosphorylation have generally focused on determining the sites and stoichiometry of phosphorylated proteins derived from different biological specimens such as cell lines and tissue samples. While such information is important for understanding the role of phosphoryla...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD007878 | Pride
Protein stability Phosphorylation Human breast cancer Protein conformation 
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
ProteomicsDiscovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements
The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies. Together the SILAC- and iTRAQ-S...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006732 | Pride
Silac Tamoxifen Sprox Mcf-7 N-desmethyl tamoxifen 
ProteomicsSmall molecules reveal differential shifts in stability and protein binding for G-quadruplex RNA
The potential of therapeutically targeting RNA with small molecules continues to grow yet progress is hindered by difficulties in determining specific mechanisms of action, including impacts on RNA-protein binding. RNA G-quadruplexes (rGQs) are a particularly promising target due to their range of b...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD060264 | Pride
Proteomics Rna Sprox 
TranscriptomicsGenome-scale analysis of Staphylococcus aureus reveals host-specific diversification of the core genome.
Staphylococcus aureus causes disease in humans and a wide array of animals. Of note, S. aureus mastitis of ruminants, including cows, sheep and goats, results in major economic losses worldwide. Extensive variation in genome content exists among S. aureus pathogenic clones. However, the genomic vari...
ORGANISM(S): Staphylococcus aureus 
2008-11-18 | E-GEOD-10187 | biostudies-arrayexpress
UnknownViral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19.
Not available
S-EPMC11175705 | biostudies-literature
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
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