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ProteomicsInteractome of the TCF3-HLF fusion protein
Oncogenic chimeric transcription factors are central drivers in cancer. To understand how the TCF3-HLF fusion protein rewires the transcriptional landscape in t(17;19) positive leukemia, functional genetic and proteomic experiments were conducted. In this dataset, the protein-protein interactions of...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD014992 | Pride
Flag-tagged fusion protein Ap-ms 
GenomicsMolecular mechanism of EPC1-PHF1 fusion protein (ChIP-seq Homo Sapiens)
Molecular mechanism of EPC1-PHF1 fusion protein (ChIP-seq Homo Sapiens)
PRJNA680614 | ENA
TranscriptomicsChromatin immunoprecipitation of human HEK293 cells with flag-tagged IMP1 antibody
Isolation of IMP1 bound mRNAs. Flag-tagged IMP1 was expressed in HEK293 cells. Flag tagged IMP1 was immunoprecipitated and mRNAs isolated. As controls HEK293 cells that do not express Flag-tagged IMP1 was included.
ORGANISM(S): Homo sapiens 
2006-12-31 | E-MEXP-841 | biostudies-arrayexpress
TranscriptomicsComparative expression profiling identifies differential roles for Myogenin and p38M-NM-1 MAPK signaling in myogenesis
Mitogen activated protein kinase (MAPK) signaling regulates differentiation of many cell types. During myogenesis in particular, p38a MAPK (MAPK14) phosphorylates multiple transcriptional regulators to modulate muscle-specific gene expression. Among the p38a MAPK modulated genes is the muscle-specif...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-25763 | biostudies-arrayexpress
ProteomicsGPIF constrains Polycomb Repressive Complex 2 activity in germ cells
The project aimed at identifying the cofactors regulating Polycomb complex PRC2 enzymatic activity in gonads. We used a knock-in mouse model where the enzymatic subunit of PRC2 (either EZH2 or EZH1) is tagged (Flag-tag) to purify PRC2 from mouse adult testis. This experiment revealed the existence o...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-07-22 | PXD012354 | Pride
Histone Chromatin Methylation Polycomb. 
GenomicsSTAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-50993 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylated residues on human MX2 obtained from 293T cells
Determination of MX2 positions subjected to phosphorylation using C-terminally Flag-tagged protein overexprtessed in 293T cells on on an Orbitrap Fusion Lumos.
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD026090 | Pride
Interferon Mx2 Ptm Antiviral Phosphorylation 
TranscriptomicsTEAD4 occupied genes in differentiated C2C12 myoblasts
The TEAD (1-4) transcription factors comprise the conserved TEA/ATTS DNA binding domain recognising the MCAT element in the promoters of muscle-specific genes. Despite extensive genetic analysis, the function of TEAD factors in muscle differentiation has proved elusive due to redundancy amongst the ...
ORGANISM(S): Mus musculus 
2011-08-21 | E-GEOD-29208 | biostudies-arrayexpress
GenomicsFusion partner directed chromatin occupancy drives the transcriptome heterogeneity of MLL-fusion acute lymphoblastic leukemia
Fusion partner directed chromatin occupancy drives the transcriptome heterogeneity of MLL-fusion acute lymphoblastic leukemia
PRJNA407757 | ENA
ProteomicsFLAG-BIo-tagged MAT2A interactome analysis in HeLa cells
MAT2A is the enzyme synthesising S-adenosylmethionine which is utilized as the primary methyl group donor in biological methylation.HeLa cells that stably expressed the FLAG-Bio-tagged mouse MAT2A protein were established by retroviral infection. The FLAG-Bio-MAT2A cells, as well as normal HeLa cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-21 | MSV000089292 | MassIVE
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