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ProteomicsMX2 Viral Substrate Breadth and Inhibitory Activity Are Regulated by Protein Phosphorylation
Productive infection by human immunodeficiency virus type-1 (HIV-1) requires the import of viral replication complexes into the nuclei of infected cells. Myxovirus resistance 2 (MX2/MxB) blocks this step, halting nuclear accumulation of viral DNA and virus replication. Here, we identify positions in...
ORGANISM(S): Homo sapiens (Human) 
2022-07-21 | PXD035305 | Pride
Innate immunity Mx2 Protein phosphorylation Infection Retroviruses 
ProteomicsMX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids
Human myxovirus resistance 2 (MX2) can restrict HIV-1 and herpesviruses at a post-entry step through a process requiring an interaction between MX2 and the viral capsids. The involvement of other host cell factors, however, remains poorly understood. Here, we mapped the proximity interactome of MX2,...
ORGANISM(S): Homo sapiens (Human) 
2024-10-09 | PXD042544 | Pride
Human U87-mg Turboid Llps Hsv-1 Mx2 Bioid Hiv-1 Condensates Lc-ms/ms 
GenomicsDietzia maris strain:MX2
Dietzia maris strain:MX2 Genome sequencing and assembly
PRJNA990763 | ENA
ProteomicsIdentification of cellular binders of human MX2 through a 3-labels SILAC based experiment using 293T cells protein over-expression and affinity purification
3 labels SILAC experiment searching for binding interactors of human MX2 through comparison of binding protein ratios against human MX1, mutant MX2 R11-13A or mock-transfected 293T cells. Also comparison of binders from a chimeric GFP protein bearing the amino-terminal domain of MX2 against GFP.
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD026073 | Pride
Human Interferon Mx2 Mx1 
ProteomicsIdentification of phosphorylated residues on human MX2 obtained from 293T cells
Determination of MX2 positions subjected to phosphorylation using C-terminally Flag-tagged protein overexprtessed in 293T cells on on an Orbitrap Fusion Lumos.
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD026090 | Pride
Interferon Mx2 Ptm Antiviral Phosphorylation 
TranscriptomicsRNA-Seq of human AML cell line, HL-60 and its mitoxantrone resistant subline HL60/MX2
Alteration in metabolic repertoire is commonly associated with resistance phenotype. Although it’s a common phenotype, not much efforts have been undertaken to design effective strategies to target the metabolic drift in such cancerous cells and especially with drug resistant properties. In our stud...
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-8981 | biostudies-arrayexpress
TranscriptomicsRNA-seq for siPRKDC and siControl in human HL-60/MX2 mitoxantrone resistant derivative of the HL-60 cell line
Anthracyclines, topoisomerase 2 enzyme poison that results in DNA damage, are currently used in acute myeloid leukemia (AML) treatment. Identifying the mechanisms underlying drug resistance remains an important question. Here, using a mitoxantrone-resistant cell line (HL-60/MX2), we found upregulati...
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-13769 | biostudies-arrayexpress
UnknownHost and viral determinants of Mx2 antiretroviral activity.
Not available
S-EPMC4097781 | biostudies-literature
GenomicsMX2 mediates establishment of interferon response profile, regulates XAF1 and can sensitize melanoma cells to targeted therapy
MX2 mediates establishment of interferon response profile, regulates XAF1 and can sensitize melanoma cells to targeted therapy
PRJNA706026 | ENA
UnknownOligomerization Requirements for MX2-Mediated Suppression of HIV-1 Infection.
Not available
S-EPMC4702540 | biostudies-literature
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