Sort   by:  
 Page size 
TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
GenomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (Chip-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56567 | biostudies-arrayexpress
TranscriptomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (RNA-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56568 | biostudies-arrayexpress
UnknownInduced prion protein controls immune-activated retroviruses in the mouse spleen.
Not available
S-EPMC2063463 | biostudies-literature
ProteomicsEndogenous retroviruses promote prion-like spreading of proteopathic seeds
Prion-like spreading of protein misfolding is characteristic for neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigene...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-18 | PXD043201 | Pride
N2a Prion Retrovirus 
ProteomicsMorc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1 mediated H3K9me3 and DNA methylation. However, the protein network which r...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027368 | Pride
Morc3 Endogenous retroviruses Erv Histone h3.3 Daxx Setdb1 
TranscriptomicsSETDB1 Represses Endogenous and Exogenous Retroviruses in B Lymphocytes [RNA-Seq]
Genome stability relies on epigenetic mechanisms that enforce repression of endogenous retroviruses (ERVs). Current evidence suggests that distinct chromatin-based mechanisms repress ERVs in cells of embryonic origin (histone methylation-dominant) versus more differentiated cells (DNA methylation-do...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-69464 | biostudies-arrayexpress
ProteomicsDifferences and commonalities in plasma membrane recruitment of the two morphogenetically distinct retroviruses HIV-1 and MMTV
The targeting of retroviral Gag polyproteins to the inner leaflet of the plasma membrane is mediated by the N-terminal matrix (MA) domain of Gag. Since retroviruses of different morphogenetic types assemble their immature particles in distinct regions of the host cell, the mechanism of plasma membra...
ORGANISM(S): Human immunodeficiency virus 1 Mouse mammary tumor virus 
2020-05-18 | PXD018604 | Pride
Hiv-1 Covalent labeling-mass spectrometry Matrix protein Mmtv 
UnknownA Sister Lineage of Sampled Retroviruses Corroborates the Complex Evolution of Retroviruses.
Not available
S-EPMC7947760 | biostudies-literature
ProteomicsHijacking of transcriptional condensates by endogenous retroviruses
Heterochromatin plays essential roles in repressing retrotransposons, e.g. endogenous retroviruses (ERVs) during mammalian development, but the contribution of retrotransposition to lethality observed in embryonic cells deficient for heterochromatin-mediated ERV repression is poorly understood. Here...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD021895 | Pride
Transposable elements Heterochromatin Transcriptional condensates 
Sort   by:  
 Page size