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ProteomicsDifferences and commonalities in plasma membrane recruitment of the two morphogenetically distinct retroviruses HIV-1 and MMTV
The targeting of retroviral Gag polyproteins to the inner leaflet of the plasma membrane is mediated by the N-terminal matrix (MA) domain of Gag. Since retroviruses of different morphogenetic types assemble their immature particles in distinct regions of the host cell, the mechanism of plasma membra...
ORGANISM(S): Human immunodeficiency virus 1 Mouse mammary tumor virus 
2020-05-18 | PXD018604 | Pride
Hiv-1 Covalent labeling-mass spectrometry Matrix protein Mmtv 
TranscriptomicsExpression data of breast tumors in MMTV-PyMT+ female mice treated with DPM or vehicle
Dipyridamole (DPM) is widely used to prevent strokes and vascular thrombosis. Combination therapy of DPM and antimetabolites has shown synergistic anticancer activity. This study investigated the chemopreventive effects of DPM in the mouse mammary tumor virus promoter driven polyoma middle T oncopro...
ORGANISM(S): Mus musculus 
2013-06-06 | E-GEOD-43833 | biostudies-arrayexpress
TranscriptomicsExpression data of MMTV-PyMT mice mammary tumor with or without JAM-A
Junction Adhesion Molecule-A (JAM-A) is present on leukocytes and platelets where it promotes cell adhesion and motility. We are interested in an interaction between JAM-A and tumor progression/metastases. To address this point, we mated JAM-A-/- mice and mouse mammary tumor model MMTV-PyMT mice whi...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-22555 | biostudies-arrayexpress
TranscriptomicscaArray_green-00155: Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice
Comparison the gene expression profiles of mouse mammary tumors derived from MMTV-PyMT transgenic in five different strains including FVB/NJ, I/LnJ F1, NZB/B1NJ F1, MOLF/Ei F1 and LP/J F1 and identification of signatures of tumor virulence. **NOTE: Migrated from caArray 1.x, identifier='gov.nih.nci....
ORGANISM(S): Mus musculus 
2015-06-20 | E-GEOD-70052 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse tumoros from cdc25a over-expressing animals - (MMTV-cdc25a;MMTV-neu and MMTV-neu
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4114 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of mouse cell lines MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4767 | biostudies-arrayexpress
TranscriptomicsExpression data from MMTV-PDK1 transgenic mice
The role of PDK1 on mammary tumorigenesis and its interaction with PPARdelta, was assessed. Transgenic mice were generated in which PDK1 was expressed in the mammary epithelium. We used microarrays to analyse global gene expression changes in MMTV-PDK1 transgenic mice versus wild-type mice and deter...
ORGANISM(S): Mus musculus 
2011-02-05 | E-GEOD-27083 | biostudies-arrayexpress
TranscriptomicsDifferentiation of Mammary Tumors and Reduction in Metastasis Upon Malat1 LncRNA Loss
Genome-wide analyses have identified thousands of long non-coding RNAs (lncRNAs). Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genomic loss, as well as systemic knockdown of Mal...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67647 | biostudies-arrayexpress
TranscriptomicsExpression data from mammary macrophages isolated from MMTV-iFGFR1 transgenic mice
The goal of this experiment was to profile macrophages from mammary glands isolated from transgenic mice that express inducible FGFR1 in mammary epithelial cells (MMTV-iFGFR1 transgenic mice). The mice were treated with with dimerizer to activates iFGFR1 for 48 hours and 4 weeks to induce mammary hy...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-36477 | biostudies-arrayexpress
ProteomicsMMTV-NEU-NDL-YD5 TUMOR AND BENIGN LCMS
We comprehensively assessed the total and mitochondrial proteome in the MMTV-NEU-NDL-YD5 murine model of HER2-driven mammary cancer.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD071897 | Pride
Benign Mammary Cancer Mmtv Tumor 
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