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MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
TranscriptomicsExpression data from DC-induced Hopx-deficient and sufficient regulatory T cells after immunization
We found that Hopx is required for the function of DC-induced regulatory T cells in vivo. We used microarrays to identify relevant Hopx-targets in such cells after antigenic re-challenge in vivo. CD25/Foxp3 double positive DC-induced Hopx-deficient and sufficient regulatory T cells were FACS sorted ...
ORGANISM(S): Mus musculus 
2010-08-29 | E-GEOD-23167 | biostudies-arrayexpress
ProteomicsProtemics of Mettl3-deficient NK cells
With mass spectrometry， we aim to find the differentially expressed proteins in Mettl3-deficient NK cells
ORGANISM(S): Mus Musculus 
PXD025823 |
TranscriptomicsMouse CD4+/CD8+ thymocytes from miR-181a1/b1 KO vs WT
miR-181a1/b1, miR-181a2/b2, and miR-181c/d belong to a highly conserved family of microRNA clusters, yet their role in vivo is poorly understood. Here we show that the miR-181a1/b1 cluster is absolutely essential for NKT development and is a critical determinant of thymocyte proliferation, survival ...
ORGANISM(S): Mus musculus 
2014-04-09 | E-GEOD-41090 | biostudies-arrayexpress
TranscriptomicsCoexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-53514 | biostudies-arrayexpress
UnknownIRF8-dependent molecular complexes control the Th9 transcriptional program.
Not available
S-EPMC5727025 | biostudies-literature
UnknownCD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T<sub>H</sub>1 and T<sub>H</sub>9 cells.
Not available
S-EPMC8804688 | biostudies-literature
UnknownHIV-1 Vpu restricts Fc-mediated effector functions in vivo.
Not available
S-EPMC9703018 | biostudies-literature
UnknownModulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir.
Not available
S-EPMC8214472 | biostudies-literature
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