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TranscriptomicsTranscription profiling of Drosophila infected with the parasitoid wasps Leptopilina boulardi and L. heterotoma to investigate infection strategies
Although host-parasitoid interactions are becoming well characterized at the organismal and cellular levels, much remains to be understood of the molecular bases for the host immune response and the parasitoids’ ability to defeat this immune response. Leptopilina boulardi and L. heterotoma, two c...
ORGANISM(S): Drosophila melanogaster 
2008-03-13 | E-GEOD-8938 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of spotted-dick in Drosophila S2 cells
Drosophila S2 cells treated with either GFP or spotted-dick dsRNA and incubated for 5 days. There are three replicates for each condition.
ORGANISM(S): Drosophila melanogaster 
2007-07-06 | E-GEOD-2623 | biostudies-arrayexpress
TranscriptomicsSpotted Dick Chromatin Immunopurification
Chromatin enriched by immunopurification with antibodies against the Drosophila transcription factor spotted dick compared with pre immune sera on a cDNA microarray
ORGANISM(S): Drosophila melanogaster 
2010-06-10 | E-GEOD-2632 | biostudies-arrayexpress
TranscriptomicsA Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders
Human peroxisome biogenesis disorders are lethal genetic disease in which abnormal peroxisome assembly compromises overall peroxisome and cellular function. Peroxisomes are ubiquitous membrane-bound organelles involved in several important biochemical processes, notably lipid metabolism and the use ...
ORGANISM(S): Drosophila melanogaster 
2011-07-02 | E-GEOD-30362 | biostudies-arrayexpress
TranscriptomicsThe CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Homo sapiens 
2010-10-18 | E-GEOD-23349 | biostudies-arrayexpress
TranscriptomicsThe gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons
A challenge in systems biology is to understand the gene regulatory networks that connect early cellular specification to terminal differentiation of specific cell types. In neurogenesis, neural specification has been well studied, but the link between the proneural transcriptional regulators of spe...
ORGANISM(S): Drosophila melanogaster 
2011-02-18 | E-GEOD-21520 | biostudies-arrayexpress
TranscriptomicsCrebA is a major and direct regulator of secretory pathway gene expression
Abstract: Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary and mammary glands. Here, we report that the CrebA/Creb3-like family of bZip transcription factors functions to upregul...
ORGANISM(S): Drosophila melanogaster 
2010-10-18 | E-GEOD-23346 | biostudies-arrayexpress
ProteomicsProximity labelling reveals effects of disease-causing mutations on the DNAJC5/cysteine string protein α interactome
Cysteine string protein α (CSPα), also known as DNAJC5, is a member of the DnaJ/Hsp40 family of co-chaperones. The name derives from a cysteine-rich domain, palmitoylation of which enables localization to intracellular membranes, notably neuronal synaptic vesicles. Mutations in the DNAJC5 gene that ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-04 | PXD037258 | Pride
Exocytosis Neuronal ceroid lipofuscinosis Warwick_rtp Miniturbo Snare Pc12 cell Neurodegeneration Stxbp1 
TranscriptomicsVariation in homeodomain DNA-binding revealed by high-resolution analysis of sequence preferences
Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the majority (168) of mouse homeodomains to all possible 8-base sequences, re...
ORGANISM(S): Mus musculus 
2010-06-26 | E-GEOD-11239 | biostudies-arrayexpress
UnknownExpression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
Not available
S-EPMC6745702 | biostudies-literature
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