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ProteomicsActivity-based protein profiling of xylan-degrading glycoside hydrolases in Aspergillus secretomes
Plant polysaccharides represent a virtually unlimited feedstock for the generation of biofuels and other commodities. However, the extraordinary recalcitrance of plant polysaccharides towards breakdown necessitates a continued search for enzymes that degrade these materials efficiently under defined...
ORGANISM(S): Aspergillus Niger (ncbitaxon:5061) 
2019-04-24 | MSV000083714 | MassIVE
UnknownUsing BONCAT to dissect the proteome of <i>S. aureus</i> persisters.
Not available
S-EPMC12482189 | biostudies-literature
ProteomicsActivity-based protein profiling in human M2 macrophages using DHA-based photoaffinity probes
17-Hydroxydocosahexaenoic acid (17-HDHA), an oxidative metabolite of the fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3), is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of 17-HDHA are poorly understood. Here, we report the ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD027600 | Pride
Human Abpp Photoaffinity Macrophage 
ProteomicsDiscovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
N‑acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids. Using a high-through...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017586 | Pride
Lipids Drug discovery Endocannabinoids Chemical biology 
UnknownNew Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes.
Not available
S-EPMC6343074 | biostudies-literature
ProteomicsProfiling the anandamide reuptake inhibitor WOBE437
Anandamide, or N-arachidonoylethanolamine (AEA), is a signaling lipid that modulates neurotransmitter release via activation of the cannabinoid receptor type 1 (CB1R) in the brain. Termination of anandamide signaling is thought to be mediated via a facilitated cellular reuptake process utilizing an ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD031488 | Pride
Abpp Photoaffinity Proteomics Endocannabinoid 
UnknownComparative Photoaffinity Profiling of Omega-3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages.
Not available
S-EPMC9585591 | biostudies-literature
UnknownTreatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma.
Not available
S-EPMC7611616 | biostudies-literature
MetabolomicsA pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella

Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge essential nutrients from the host has been an open question due to the difficulties in distinguishing between bacterial and host metabolites

2023-08-02 | MTBLS1275 | MetaboLights
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