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ProteomicsFunctional Mapping of the Trypanosoma cruzi Serinome by Fluorophosphonate Activity-Based Protein Profiling
Serine hydrolases (SHs) constitute one of the largest enzyme superfamilies in eukaryotes, yet their roles in Trypanosoma cruzi, the causative agent of Chagas disease, remain largely uncharacterized. Here, we report an activity-based chemoproteomic map of the T. cruzi epimastigote serinome by combini...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2026-07-21 | PXD080813 | Pride
Activity-based protein profiling Chagas disease Fluorophosphonate probes Serine hydrolases Trypanosoma cruzi 
UnknownProfiling Serine Hydrolases in the Leishmania Host-Pathogen Interactome Using Cell-Permeable Activity-Based Fluorophosphonate Probes.
Not available
S-EPMC12117450 | biostudies-literature
Proteomicshuman MS Lesions ABPP - foamy microglia link oxylipins to disease progression in multiple sclerosis
In this study lesions from human MS brains and controls were isolated and analyzed by Activity-based protein profiling using fluorophosphonate- and beta-lacton probes to enrich active enzymes from the samples. these were subsequently analyzed by LC/MS-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD056899 | Pride
Multiple sclerosis Activity-based protein profiling Serine hydrolase Lesions Brain Chemical proteomics Fluorophosphonate 
UnknownAn improved synthesis of a fluorophosphonate-polyethylene glycol-biotin probe and its use against competitive substrates.
Not available
S-EPMC3566859 | biostudies-literature
UnknownLate-Stage Conversion of Diphenylphosphonate to Fluorophosphonate Probes for the Investigation of Serine Hydrolases.
Not available
S-EPMC6897304 | biostudies-literature
ProteomicsDiscovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides
A unified synthesis of skeletally-diverse sulfonyl fluorides was developed that relied upon photoredox-catalysed dehydrogenative couplings between hetaryl sulfonyl fluorides and hydrogen donor building blocks. A set of 32 diverse probes were prepared, and then screened against Trypanosoma brucei. ...
ORGANISM(S): Trypanosoma brucei 
2024-10-16 | PXD056504 | Pride
Medicinal chemistry Photoredox chemistry Chemoproteomics Sulfonyl fluoride 
UnknownFluorescent Triazole Urea Activity-Based Probes for the Single-Cell Phenotypic Characterization of Staphylococcus aureus.
Not available
S-EPMC6456404 | biostudies-literature
UnknownDevelopment of Single-Molecule Enzyme Activity Assay for Serine Hydrolases Using Activity-Based Protein Labeling Probes.
Not available
S-EPMC12641359 | biostudies-literature
UnknownBiochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response.
Not available
S-EPMC10644348 | biostudies-literature
ProteomicsPredictive chemoproteomics and functional validation reveal Coeae6g mediated insecticide cross-resistance in the malaria vector Anopheles gambiae
This project investigates insecticide resistance mechanisms in Anopheles gambiae using Activity-Based Protein Profiling (ABPP). By targeting serine hydrolases (SHs) with fluorophosphonate (FP) probes and mass spectrometry, we identified COEAE6G as a key enzyme conferring resistance to Pirimiphos-met...
ORGANISM(S): Anopheles gambiae str. PEST 
2025-10-17 | PXD060698 | Pride
Resistance Anopheles gambiae Pirimiphos-methyl Abpp 
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