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MetabolomicsEffect of genetic lesions on glioblastoma (NP, NPA, NPAI, NS)
Not available
ORGANISM(S): Mus musculus 
ST000714 | MetabolomicsWorkbench
ProteomicsFallopian tube lesions as potential precursors of early ovarian cancer: A comprehensive proteomic analysis.
The main goal of this study is to explore the proteomic expression in prophylactic salpingooophorectomy specimens, obtained from highly selected cohort of patients at risk of developing a high-grade serous ovarian carcinoma (HGSOC), because of a hereditary (BRCA 1 or 2 mutation) or a documented fami...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD020024 | Pride
Pre-neoplastic lesions Oavrian cancer Spatially resolved proteomics Ihc Proteomics 
ProteomicsSerum Proteomic Profiling Reveals Immune and Inflammatory Mechanisms Driving Susceptibility to Buffalo Fly-Induced Skin Lesions in Cattle
Buffalo fly (Haematobia irritans exigua) infestation in cattle poses a significant challenge to animal health and welfare, causing blood loss and often painful skin lesions. These lesions can reduce the value of cattle in saleyards, make cattle unacceptable for certain markets, and provide a focus f...
ORGANISM(S): Bos taurus (Bovine) 
2026-01-12 | PXD066231 | Pride
Acute phase response Susceptibility Buffalo fly (haematobia irritans exigua) Immune dysregulation Cattle Quantitative proteomics Biomarkers Skin lesions 
TranscriptomicsStereo-seq analysis of human multiple sclerosis white matter lesions
Fresh frozen samples from human white matter MS lesions. Using Stereo-seq we compared mixed active/inactive lesions with lipid-laden foamy microglia with lesions containing ramified microglia. Study includes post-mortem subcortical white matter (WM) tissue of n = 7 donors with MS (5 females, 2 male...
ORGANISM(S): Homo sapiens 
2026-05-11 | E-MTAB-17040 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lung tissues from patients with combined pulmonary fibrosis and emphysema
Combined pulmonary fibrosis and emphysema (CPFE) is characterized by upper-lobe emphysema combined with lower-lobe fibrosis and a high prevalence of pulmonary hypertension. The aim of this study was to measure and analyze gene expression profiles in the lungs of CPFE patients. The results showed tha...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-38934 | biostudies-arrayexpress
TranscriptomicsIdentifying host pathogenic pathways in bovine digital dermatitis by RNA-Seq analysis of lesions
Digital dermatitis is a painful foot disease compromising welfare in dairy cattle. The disease has a complex multibacterial aetiology, but little is known about its pathogenesis. In this study, gene expression in skin biopsies from five bovine digital dermatitis lesions and five healthy bovine feet ...
ORGANISM(S): Bos taurus 
2013-03-26 | E-GEOD-41732 | biostudies-arrayexpress
TranscriptomicsMolecular analysis of precursor lesions in familial pancreatic cancer
Background: With less than a 5% survival rate pancreatic adenocarcinoma (PDAC) is almost uniformly lethal. In order to make a significant impact on survival of patients with this malignancy, it is necessary to diagnose the disease early, when curative surgery is still possible. Detailed knowledge of...
ORGANISM(S): Homo sapiens 
2013-03-27 | E-GEOD-43288 | biostudies-arrayexpress
TranscriptomicsProfiling premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis
Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epithelium, therefore studying these lesions is critical for understanding lung carcinogenesis. We performed RNA sequencing on laser-microdissected representative cell populations along the SCC pathologica...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-49155 | biostudies-arrayexpress
TranscriptomicsChromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas
Cervical cancer develops from pre-cancerous high-grade cervical intraepithelial neoplasia (CIN) lesions harbouring a transforming infection with high-risk human papillomavirus (hrHPV), which is characterised by p16INK4a overexpression. Since it takes one or more decades for these pre-cancerous lesio...
ORGANISM(S): Homo sapiens 
2009-02-19 | E-GEOD-11573 | biostudies-arrayexpress
Proteomicshuman MS Lesions ABPP - foamy microglia link oxylipins to disease progression in multiple sclerosis
In this study lesions from human MS brains and controls were isolated and analyzed by Activity-based protein profiling using fluorophosphonate- and beta-lacton probes to enrich active enzymes from the samples. these were subsequently analyzed by LC/MS-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD056899 | Pride
Multiple sclerosis Activity-based protein profiling Serine hydrolase Lesions Brain Chemical proteomics Fluorophosphonate 
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