Chromosomal signatures of a subset of high-grade premalignant cervical lesions closely resemble invasive carcinomas

ABSTRACT: Cervical cancer develops from pre-cancerous high-grade cervical intraepithelial neoplasia (CIN) lesions harbouring a transforming infection with high-risk human papillomavirus (hrHPV), which is characterised by p16INK4a overexpression. Since it takes one or more decades for these pre-cancerous lesions to progress to invasive squamous cell carcinomas (SCCs), it is obvious that they are heterogeneous in terms of duration of existence and progression risk. We performed array-based comparative genomic hybridisation (array CGH) of 46 p16INK4a immuno-positive CIN2/3 lesions to determine whether this heterogeneity is reflected in their chromosomal profiles. Chromosomal profiles of CIN2/3 lesions were related to those of invasive cervical squamous cell carcinomas (SCCs) and promoter methylation o

ORGANISM(S): Homo sapiens

SUBMITTER: Serge Smeets 

PROVIDER: E-GEOD-11573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress