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TranscriptomicsExpression data from MDA-MB-231 cell line treated with Zoledronate, or Fluvastatin, or mock-treated control cells.
Statins and bisphosponates (BPs) are two distinct classes of isoprenoid pathway inhibitors targeting HMG-CoA reductase (upstream enzyme) and Farnesyl-pyrophospate synthase (downstream enzyme) respectively. Here we conducted a comparative study of two representatives of these classes, fluvastatin (Fl...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33552 | biostudies-arrayexpress
TranscriptomicsEffects of fluvastatin treatment on monocyte gene expression in SLE patients
The present gene expression array study of fluvastatin effects on monocytes from SLE patients show that fluvastatin has a global anti-inflammatory effect on monocytes, which includes attenuated expression of several proinflammatory cytokines, and regulated expression of molecules mediating lipoprote...
ORGANISM(S): Homo sapiens 
2014-03-12 | E-GEOD-45422 | biostudies-arrayexpress
ProteomicsFluvastatin mitigates SARS-CoV-2 infection in human lung cells
Clinical data of patients suffering from COVID-19 have indicated that statin therapy, used to treat hypercholesterolemia, is associated with a better clinical outcome. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that fluvastatin inhibited cor...
ORGANISM(S): Homo sapiens (Human) 
2021-12-07 | PXD023422 | Pride
Hypercholesteremia Sars-cov-2 Risk factor Proteomics Air-liquid-interface culture Cholesterol Virus Fluvastatin Statin Covid-19 
ProteomicsEffect of fluvastatin-treatment on the proteome and phosphor-proteome in metastatic pancreatic cancer cells
Fluvastatin has been identified as novel inhibitors of metastasis in pancreatic cancer. In multiple in vivo and in vitro experiments the compounds phenotypic effects was validated. Since under drug treatment the transcriptomic changes in examined cell lines were rather small, we expected the underly...
ORGANISM(S): Homo sapiens (Human) 
2021-11-29 | PXD022345 | Pride
Pancreatic cancer Fluvastatin Statins 
GenomicsSignature of acquired resistance to fluvastatin
Signature of acquired resistance to fluvastatin
PRJNA731047 | ENA
TranscriptomicsFluvastatin-induced differential global gene expression in human malignant MCF-7 breast cancer cells
The current study analyzed the altered expression profiles of genes that are responsible for fluvastatin-induced breast cancer cell death in MCF-7 cells (ER+ve luminal breast cancer cells). Some of these altered gene expressions were further inter connceted to various pathways which may eventually b...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59006 | biostudies-arrayexpress
TranscriptomicsFluvastatin-induced differential global gene expression in human metastatic MDA-MB-231 breast cancer cells
The current study analyzed the altered expression profiles of genes that are responsible for fluvastatin-induced breast cancer cell death in MDA-MB-231 cells (ER-ve basal breast cancer cells). Some of these altered gene expressions were further inter connceted to various pathways which may eventuall...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59007 | biostudies-arrayexpress
GenomicsGene Expression of A375 Cells After Fluvastatin Treatment
Gene Expression of A375 Cells After Fluvastatin Treatment
PRJNA674663 | ENA
GenomicsExpression data from ASPC1-GFP PDAC cells treated with fluvastatin
Expression data from ASPC1-GFP PDAC cells treated with fluvastatin
PRJNA678661 | ENA
UnknownEnantiospecific Pharmacogenomics of Fluvastatin.
Not available
S-EPMC6767327 | biostudies-literature
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