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TranscriptomicsComparison of Glomerular Transcriptome Profiles of Adult-Onset Steroid Sensitive Focal Segmental Glomerulosclerosis and Minimal Change Disease
To search for biomarkers to differentiate Adult-Onset Steroid Sensitive focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Compared the profiles of glomerular transcriptomes between patients with FSGS and patients with MCD using microarray analysis. This dataset is part of ...
ORGANISM(S): Homo sapiens 
2017-01-04 | E-GEOD-69814 | biostudies-arrayexpress
TranscriptomicsBulk-RNAseq data of podocytes treated with FSGS sera
Human immortalised podocytes were exposed to 10% sera from a patient with focal segmental glomerulosclerosis when they were presenting with disease, on weekly vincristine treatment, and in remission. RNA was extracted with the Qiagen RNEasy plus kit, purity and concentration were assessed by nanodro...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14604 | biostudies-arrayexpress
GenomicsExon Level Expression Profiling of focal segmental glomerulosclerosis
Exon Level Expression Profiling of focal segmental glomerulosclerosis
PRJNA496420 | ENA
GenomicsTranscriptome analysis of tubular tissues of focal segmental glomerulosclerosis patients
Transcriptome analysis of tubular tissues of focal segmental glomerulosclerosis patients
PRJNA496321 | ENA
GenomicsTranscriptome analysis of tubulointerstitial tissues of patients with focal segmental glomerulosclerosis
Transcriptome analysis of tubulointerstitial tissues of patients with focal segmental glomerulosclerosis
PRJNA517486 | ENA
ProteomicsRing study of patients suffering from focal segmental glomerulosclerosis as a proof of concept for federated proteomics.
Quantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD053560 | Pride
Focal segmental glomerulosclerosis Serum Federated proteomics Kidney Federated learning 
ProteomicsPathogenesis of focal segmental glomerulosclerosis and minimal change disease
Podocyte injury is the hallmark of both focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) and is ultimately reflected in foot process effacement proteinuria. Triggers and pathogenic pathways leading to podocyte cytoskeleton rearrangements are however incompletely explained. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-12 | MSV000097297 | MassIVE
ProteomicsLaser microdissection and mass spectrometry shows loss of podocyte proteins in minimal change disease and focal segmental glomerulosclerosis.
Minimal change disease and primary focal segmental glomerulosclerosis (FSGS) are common causes of nephrotic syndrome. Both diseases present with massive proteinuria and widespread foot process effacement on electron microscopy examination. On the other hand, secondary FSGS can also present with sign...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD057165 | Pride
Laser microdissection Focal segmental glomerulosclerosis Mass spectrometry Minimal change disease 
ProteomicsDysregulated proteases homoeostasis in primary focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) represents a pattern of injuries seen in histopathology rather than a distinct disease. Presently, FSGS is categorized into primary, genetic, and secondary types, although these subcategories probably encompass significantly diverse pathogeneses. Here, we pe...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD058875 | Pride
Serpina1 Pfsgs Proteomics Tmt Par1 Proteases Zebrafish Dda 
ProteomicsAnti-nephrin autoantibodies in minimal change disease and focal segmental glomerulosclerosis (proteomics)
Background: Minimal change disease (MCD) and focal-segmental glomerulosclerosis (FSGS) are immune-mediated glomerular diseases manifesting as nephrotic syndrome. Autoantibodies against the podocyte slit diaphragm protein nephrin were recently identified in a subset of patients with minimal change di...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-27 | PXD047417 | Pride
Focal segmental glomerulosclerosis (fsgs) Proteomics Minimal change disease (mcd) Autoantibodies Phospho-proteomics Kidney disease Nephrin 
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