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TranscriptomicsBT474 and BT474-J4 microarray data
These data provide scientific information to understand the mechanism of action of lapatinib resistance in HER2-positive patients and to test the combination of HER2-targeted agents and GSK1363089 (foretinib) in the clinic by using an acquired lapatinib-resistant cell line. Cell lines (BT474, an HER...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-16179 | biostudies-arrayexpress
ProteomicsDivergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative differential effects on individual targets: Drug Pulldowns
Despite recent successes of precision and immunotherapies there is a persisting need for novel targeted or multi-targeted approaches in complex diseases. Through a systems pharmacology approach including phenotypic screening, chemical and phosphoproteomics and RNA-Seq, we elucidated the targets and ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD012961 | Pride
Cabozantinib Chemical proteomics Polypharmacology Foretinib Lung cancer 
ProteomicsDivergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative differential effects on individual targets: Tyrosine Phosphorylation
Despite recent successes of precision and immunotherapies there is a persisting need for novel targeted or multi-targeted approaches in complex diseases. Through a systems pharmacology approach including phenotypic screening, chemical and phosphoproteomics and RNA-Seq, we elucidated the targets and ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD012962 | Pride
Cabozantinib Phosphotyrosine Polypharmacology Foretinib Lung cancer 
ProteomicsDivergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative differential effects on individual targets: ABPP
Despite recent successes of precision and immunotherapies there is a persisting need for novel targeted or multi-targeted approaches in complex diseases. Through a systems pharmacology approach including phenotypic screening, chemical and phosphoproteomics and RNA-Seq, we elucidated the targets and ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD012965 | Pride
Abpp Cabozantinib Polypharmacology Foretinib Lung cancer 
ProteomicsDivergent polypharmacology-driven cellular activity of structurally similar multi-kinase inhibitors through cumulative differential effects on individual targets: IMAC Phosphoproteomics
Despite recent successes of precision and immunotherapies there is a persisting need for novel targeted or multi-targeted approaches in complex diseases. Through a systems pharmacology approach including phenotypic screening, chemical and phosphoproteomics and RNA-Seq, we elucidated the targets and ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD012963 | Pride
Phosphoproteomics Cabozantinib Imac Polypharmacology Foretinib Lung cancer 
UnknownCombination effect of lapatinib with foretinib in HER2 and MET co-activated experimental esophageal adenocarcinoma.
Not available
S-EPMC6879590 | biostudies-literature
UnknownCombination Foretinib and Anti-PD-1 Antibody Immunotherapy for Colorectal Carcinoma.
Not available
S-EPMC8298272 | biostudies-literature
UnknownForetinib Alleviates Osteoblast Senescence and Protects Against Bone Loss in Ovariectomized Mice by Promoting Osteoblast Differentiation.
Not available
S-EPMC12731566 | biostudies-literature
UnknownTargeted dual inhibition of c-Met/VEGFR2 signalling by foretinib improves antitumour effects of nanoparticle paclitaxel in gastric cancer models.
Not available
S-EPMC8178268 | biostudies-literature
UnknownA Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma.
Not available
S-EPMC5420486 | biostudies-literature
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