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ProteomicsTFIP11 competes with the Bloom syndrome helicase for binding to stalled replication forks to preserve genome stability
Replication fork reversal is a key protective mechanism against replication stress in higher eukaryotic cells and occurs via a series of coordinated enzymatic reactions. The Bloom syndrome gene product, BLM, is a member of the highly conserved RecQ helicase family and has been implicated in this pro...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042222 | Pride
Bloom syndrome helicase  replication stress  replication fork reversal  genome instability  tfip11 
UnknownReplication fork uncoupling causes nascent strand degradation and fork reversal.
Not available
S-EPMC9868089 | biostudies-literature
UnknownReplication fork reversal triggers fork degradation in BRCA2-defective cells.
Not available
S-EPMC5643541 | biostudies-literature
UnknownDNA-PKcs promotes fork reversal and chemoresistance.
Not available
S-EPMC9588680 | biostudies-literature
ProteomicsATM promotes reversed fork processing during DNA interstrand cross-link repair
During replication-coupled DNA interstrand cross-link (ICL) repair, fork reversal is thought to enable the Fanconi anemia (FA) pathway to resolve the ICL through nucleolytic incisions. Subsequent fork restoration then allows nascent DNA strand extension past the lesion. Although these fork remodelin...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-08-25 | PXD071242 | Pride
Fork reversal Interstrand cross-link Exo1 Icl repair Pp2a Fanconi anemia pathway Dna2 Atm Fork restoration Orbitrap astral mass spectrometer Wrn 
UnknownFork Reversal Safeguards Epigenetic Inheritance During Replication Stress.
Not available
S-EPMC12869582 | biostudies-literature
UnknownDisparate requirements for RAD54L in replication fork reversal.
Not available
S-EPMC11551752 | biostudies-literature
UnknownRADX prevents genome instability by confining replication fork reversal to stalled forks.
Not available
S-EPMC8286330 | biostudies-literature
UnknownReplication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.
Not available
S-EPMC6086610 | biostudies-literature
UnknownFunctional analysis of DNA replication fork reversal catalyzed by Mycobacterium tuberculosis RuvAB proteins.
Not available
S-EPMC3256873 | biostudies-literature
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