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MetabolomicsPhotorespiration is linked to DNA methylation by formate as one-carbon source.
DNA methylation is a key epigenetic modification regulating genome organization, stability, and gene expression. Stable DNA methylation critically relies on methyl groups provided through folate-mediated one-carbon (C1) metabolism, yet the origin and regulation of C1 supply remain elusive. Here we d...
2026-01-06 | MTBLS13444 | MetaboLights
ProteomicsEngineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo
To realize a carbon-neutral bioeconomy, the concept of electrobiocatalysis has been developed, in which CO2 is first chemically reduced to formate and subsequently assimilated by enzymatic cascades or engineered microbes. A key step in the assimilation of formate is its reduction into formaldehyde, ...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2023-03-22 | MSV000091532 | MassIVE
ProteomicsFormate-induced phospho-signalling
The mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor it is not obvious link between formate and pyrimidine synthesis. Methods Here we combine p...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD019347 | Pride
Metabolism Formate Phosphoproteomics Ms Cancer 
TranscriptomicsPyruvate fermentation vs Lactate-Sulfate
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8015 | biostudies-arrayexpress
ProteomicsCoupling biomanufacturing to decarbonization through hydrogen and formate-driven metabolism
Biomanufacturing processes are often constrained by cellular energy requirements that are tightly coupled to carbon metabolism in sugar-based fermentation systems. To address this limitation, we engineered Escherichia coli to use hydrogen gas (H2) and formate (HCOO-) as alternative energy sources, e...
ORGANISM(S): Escherichia coli Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2026-10-15 | PXD061595 | Pride
Nadh Renewable energy Arpa-e Formic acid Metabolic flux analysis Industrial microbiology Gas fermentation Hydrogen gas Bioenergetics 
TranscriptomicsPyruvate vs Lactate as electron donor in Sulfate reduction
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8071 | biostudies-arrayexpress
TranscriptomicsThiosulfate vs Sulfate as electron acceptor in Sulfate reduction
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8072 | biostudies-arrayexpress
TranscriptomicsHydrogen vs Lactate as electron donor in Sulfate reduction
In order to obtain a global view of energy metabolism pathways of the sulfate-reducer Desulfovibrio vulgaris Hildenborough and the proteins involved therein whole-genome microarrays were used to compare the transcriptional response of cells grown with hydrogen/sulfate, pyruvate/sulfate, lactate/thio...
ORGANISM(S): Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough 
2008-05-31 | E-GEOD-8037 | biostudies-arrayexpress
MetabolomicsUnique metabolism of different glucosinolates in larvae and adults of a leaf beetle specialised on Brassicaceae
Brassicaceae plants contain glucosinolates, which are hydrolysed by myrosinases to toxic products such as isothiocyanates and nitriles, acting as defences. Herbivores have evolved various detoxification strategies, which are reviewed here. Larvae of Phaedon cochleariae (Coleoptera: Chrysomelidae) me...
2022-11-11 | MTBLS3565 | MetaboLights
ProteomicsA quantitative metabolic analysis reveals Acetobacterium woodii as a flexible and robust host for formate-based bioproduction
Cheap and renewable feedstocks such as the one carbon substrate formate are emerging for sustainable production in a growing chemical industry. By quantitatively analyzing physiology, transcriptome, proteome in chemostat cultivations in combination with computational analyses, we investigated the ac...
ORGANISM(S): Acetobacterium woodii 
2023-03-08 | PXD026569 | Pride
Mixed gas fermentation Continuous fermentation Metabolic modelling Substrate co-utilization Acetogens Omics analysis Formate bioeconomy 
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