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ProteomicsPrecisely measured protein lifetimes in the brain of aged mice
Aging, which is associated with protein homeostasis defects, is one of the most prominent risk factors for neurodegenerative disorders and the regulation of protein homeostasis is essential for brain health. While several studies have addressed changes in protein abundance due to aging, little is kn...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD023994 | Pride
Synapse Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes 
ProteomicsThe long noncoding RNA neuroLNC modulates neurotransmitter release interacting with a neurodegeneration-associated protein
The roles of long noncoding RNAs (lncRNAs) in synaptic transmission and neuronal development are emerging. Here we applied an integrated bioinformatic/biological screening strategy to identify lncRNAs that regulate synaptic vesicle release. We identified neuroLNC, a conserved neuron-specific nuclear...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-26 | PXD013434 | Pride
Neuron Ellps Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes Glia 
ProteomicsM.musculus - Cerebral cortex, SC (Fornasieroetal,natcomm2018)
abundance based on Spectral counting, Interaction consistency score: 8.0, Coverage: 7
ORGANISM(S): 10090 
2018-00-00 | 494884207 | PAXDB
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