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ProteomicsTowards an upgraded honey bee (Apis mellifera L.) genome annotation using proteogenomics.
The honey bee is a key pollinator in many agricultural operations as well as a model organism for studying the genetics and evolution of social behaviour. The Apis mellifera genome has been sequenced and annotated twice over, enabling proteomics and functional genomics methods for probing relevant a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Apis mellifera (Honeybee) Drosophila melanogaster (Fruit fly) Saccharomyces cerevisiae (Baker's yeast) Caenorhabditis elegans 
2016-01-18 | PXD002275 | Pride
Honey bees Proteogenomics Mass spectrometry Gene annotation Apis mellifera 
ProteomicsComprehensive proteomic analysis of autophagosomes derived from Leishmania infected macrophages
Autophagy has been implicated as a host defense mechanism against intracellular pathogens. However, certain intracellular pathogens such as Leishmania can manipulate the host’s autophagy to promote their survival. Recently, our findings regarding the regulation of autophagy by Leishmania donovani in...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037057 | Pride
Parasitic infection Autophagy Autophagosome Leishmania donovani Host-pathogen interactions Lcmsms 
ProteomicsProteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis
Neurodegenerative diseases remain an area where the causative disease mechanisms, with few exceptions, are poorly understood and which are very resistant to modern therapeutic advances. Current FDA-approved medications result in modest improvements in quality of life measures and no increase in life...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2024-07-04 | MSV000095252 | MassIVE
ProteomicsProteomics on spermathecal fluid of BC queens
We sampled honey bee queens from beekeepers throughout British Columbia which were rated as either 'failed' or 'healthy' by beekeepers. We performed shot-gun proteomics on the spermathecal fluid (sperm removed). Proteins were reduced, alkylated, and digested with Lys-C for 4 h in urea digestion buff...
ORGANISM(S): Apis Mellifera 
2020-03-04 | MSV000085056 | MassIVE
ProteomicsProteome of the six eyes sand-spider Sicarius thomisoides venom
The six-eyed sand spider, Sicarius thomisoides, belongs to the Sicariidae family, whose venoms have recently been recognized for having a high toxic potential, similar to what has been demonstrated for the venom of spiders in the Loxosceles genus. However, with the exception of phospholipase D toxin...
ORGANISM(S): Sicarius thomisoides 
2025-11-10 | PXD062481 | Pride
Sicarius spider Venom proteome Lc-ms/ms 
ProteomicsmRNA-binding proteins of Leishmania donovani LC-MSMS
Leishmania are unicellular eukaryotes responsible for leishmaniasis in humans. Like other trypanosomatids, leishmania regulate protein coding gene expression almost exclusively at the post-transcriptional level with the help of RNA binding proteins (RBPs). Due to the presence of polycystronic trans...
ORGANISM(S): Leishmania donovani 
2017-02-08 | PXD005601 | Pride
Lc-msms Mrna-binding proteins Leishmania donovani Interactome capture 
ProteomicsProteomics of hygienic honey bee (A. mellifera) antenna lateralization
In other experiments, we found that hygienic honey bees show lateralized responses to odors associated with brood disease. Bees are also known to have more olfactory sensilla on their right antenna compared to their left. Following this, we performed proteomics on right and left antennae of hygienic...
ORGANISM(S): Apis mellifera (Honeybee) 
2017-12-07 | PXD005242 | Pride
Antennae Honey bee Lateralization Hygienic behaviour 
ProteomicsDynamic rewiring of the human interactome by interferon signalling
The type I interferon (IFN) response protects cells against viral pathogens by inducing the transcription of hundreds of IFN-stimulated genes (ISGs). Transcriptomic and biochemical approaches have established comprehensive catalogues of ISGs across species and cell types, but their antiviral mechani...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD013809 | Pride
Innate immunity Protein correlation profiling Proteomics Protein complexes Interferon stimulated gene Interferon Interactome 
ProteomicsProteomic investigation of Lasius niger and Bombus terrestris queen fertility
We conducted label-free, quantitative proteomics on Lasius niger queen spermathecal fluid and whole-body extracts, as well as Bombus terrestris queen spermathecal fluid and hemolymph, to investigate patterns of protein expression linked to sperm viability and reproductive stage (unmated, recently ma...
ORGANISM(S): Bombus Terrestris (ncbitaxon:30195) Lasius Niger (ncbitaxon:67767) 
2023-07-17 | MSV000092460 | MassIVE
MetabolomicsA Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.

BACKGROUND & AIMS: Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on pu...

2024-10-18 | MTBLS3476 | MetaboLights
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