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ProteomicsPALB2 acetylation by KAT2A/B (GCN5/PCAF) in vitro
PArtner and Localizer of BRCA2 (PALB2) is essential to maintain genome stability in human cells. Upon DNA damage by double DNA strand breaks, PALB2 is required to repair DNA by homologous recombination. In undamaged conditions, PALB2 protects coding regions, by preventing DNA stress due to collision...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD014681 | Pride
Acetylation Dna repair 
GenomicsGenome-wide localization of Smc1, Smc3 and CTCF in mouse B cells.
Immunoglobulin class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation induced cytidine deaminase (AID) to switch regions and by the subsequent generation and resolution of dsDNA breaks (DSBs). During, CSR the IgH locus undergoes dynamic three-dimensional...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-43594 | biostudies-arrayexpress
ProteomicsAssembly of two functionally-distinct protein import complexes in the outer membrane of plant chloroplasts (crosslinking data)
The TOC protein translocon delivers thousands of nucleus-encoded proteins to chloroplasts and to related non-photosynthetic plastids. It comprises the β-barrel channel, Toc75, and multiple isoforms of receptor GTPases, Toc33 and Toc159. However, exactly how TOC complexes are assembled in different p...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-22 | PXD064453 | Pride
ProteomicsA proteomic view of butterfly morphogenesis
Insect metamorphosis is one of the most fascinating developmental processes in the natural world. Complete metamorphosis requires the breakdown and re-organization of larval tissues, and the coordinated construction and development of adult structures. The molecular events that achieve this transfor...
ORGANISM(S): Bicyclus anynana 
2026-01-05 | PXD065563 | Pride
Whole proteome Butterfly Metamorphosis 
ProteomicsCAPTURE of the human U2 snRNA genes
In order to identify factors involved in transcription of human snRNA genes and 3’ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the tandemly-repeated U2 snRNA genes in human cell...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033580 | Pride
Transcription Snrna Interactome 
ProteomicsThe human iRHOM2 interactome upon KRAS expression
ADAM17 is a cell surface protease that controls the release of the ectodomains of signalling proteins including EGFR ligands and the primary inflammatory cytokine TNF. Reflecting this important role in signalling, dysregulated ADAM17 activity is linked to many human diseases including immunodeficien...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD063983 | Pride
Protease Signalling Rhomboid 
ProteomicsPALB2 ChAM acetylation mapping in human cells
The Chromatin Association Motif (ChAM) of the PArtner and Localizer of BRCA2 (PALB2) is essential for DNA repair function by homologous recombination in human cells. Molecular mechanisms governing ChAM interaction with chromatin remain unexplored. In this study, we have mapped acetylated lysines wit...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD014678 | Pride
Acetylation Dna repair Chromatin 
ProteomicsInteractome analysis of human Rab11a with proteins from influenza A virus infected cell lysates
The aim of this project was to determine which viral and host proteins bind to purified recombinant human GTPase Rab11a from lysates of HEK-293T cells infected with influenza A/WSN/33 (H1N1) virus. To this aim we used a GST pull-down assay. Approximately 8∙106 HEK-293T cells were infected with influ...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WSN/1933(H1N1)) 
2022-01-17 | PXD030058 | Pride
Influenza virus infection Interactome Human rab11a 
ProteomicsCharacterization of the SF3B1 interactome
CDK9 is a critical kinase required for the productive transcription of protein-coding genes by RNA polymerase II (pol II). As part of P-TEFb, CDK9 phosphorylates the carboxyl-terminal domain (CTD) of pol II and elongation factors, including SPT5, which allows pol II to elongate past the early elonga...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD033694 | Pride
Transcription Splicing Sf3b1 Interactome 
ProteomicsIdentification of AcpP-MukB binding sites using cross-linking mass spectrometry
Structural Maintenance of Chromosomes (SMC) complexes contribute ubiquitously to chromosome organization-segregation. SMC proteins have a conserved architecture, with a dimerization hinge and an ATPase head domain separated by a long antiparallel intramolecular coiled-coil. Dimeric SMC proteins inte...
ORGANISM(S): Escherichia coli 
2021-11-25 | PXD026062 | Pride
Acpp Cross-linking mass spectrometry Mukb Structural maintenance of chromosomes 
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