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ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial activity, however its precise mechanism of action during viral or bacterial infection remains elusive. We previously found that ISG15 restricts Listeria infection both in vitro and in vivo and identified IS...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-28 | PXD011513 | Pride
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral activity against several clinically relevant viruses. However, its precise mechanism of action during viral infection remains elusive. Upon infection, ISG15 conjugates to protein substrates in covalent manner. We previously f...
ORGANISM(S): Mus musculus (Mouse) Coxsackievirus 
2024-05-23 | PXD032078 | Pride
ISG15 is a ubiquitin-like modifier strongly upregulated in the type I interferon response. It exerts an antiviral function in the host defense against a wide variety of viruses. Recently, we observed that ISG15 expression restricts coxsackievirusB3 (CV) infection both in vitro and in vivo. ISG15-dep...
ORGANISM(S): Mus musculus (Mouse) Coxsackievirus 
2019-12-09 | PXD013259 | Pride
During infection, interferon production leads to upregulation of the interferon-stimulated gene 15 (ISG15) which encodes the ubiquitin-like protein ISG15. ISG15 has a profound role in restricting intracellular infection by viral and bacterial pathogens. It can exert its function either as a free int...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD018345 | Pride
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