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ProteomicsSacsin, the ARSACS disease protein, controls lysosomal positioning and reformation by regulating microtubule dynamics
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a fatal brain disorder featuring cerebellar neurodegeneration leading to spasticity and ataxia. ARSACS is caused by mutations in the SACS gene that encodes sacsin, a massive 4579 amino acid protein with multiple modular domains. H...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD033823 | Pride
Lysosome Alr Microtubule 
UnknownRapid and robust optogenetic control of gene expression in Drosophila.
Not available
S-EPMC8693864 | biostudies-literature
UnknownGenetic Counseling for Alcohol Addiction: Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members.
Not available
S-EPMC5608547 | biostudies-literature
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
UnknownEffects of Extracted Pulse Proteins on Lipid Targets for Cardiovascular Risk Reduction: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Not available
S-EPMC11548137 | biostudies-literature
ProteomicsDesign of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s disease supporting the need to discover improved inhib...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-06-09 | PXD031338 | Pride
Lc-msms Carboyxlesterase Notum Inhibitor Wnt signalling 
UnknownDeconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers.
Not available
S-EPMC5837004 | biostudies-literature
UnknownHand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial.
Not available
S-EPMC8223359 | biostudies-literature
UnknownThe tumor multi-omic landscape of endometrial cancers developed on a germline genetic background of adiposity.
Not available
S-EPMC10592984 | biostudies-literature
UnknownHormone replacement therapy (conjugated oestrogens plus bazedoxifene) for post-menopausal women with symptomatic hand osteoarthritis: primary report from the HOPE-e randomised, placebo-controlled, feasibility study.
Not available
S-EPMC9620575 | biostudies-literature
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