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TranscriptomicsThe stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
The stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria. The stringent phenotype seems to be species specific and may be mediated by fundamentally different molecular mechanisms. In Staphylococcus aureus, (p)ppGpp s...
ORGANISM(S): Staphylococcus aureus 
2013-04-05 | E-GEOD-45617 | biostudies-arrayexpress
no omics definedTranscription profiling of teicoplanin-susceptible strain of S.aureus and its teicoplanin-resistant derivative
Changes in transcriptome of S. aureus linked with acquisition of teicoplanin resistance and reduced autolysis. Comparison of RNA profiling of the teicoplanin-susceptible parental strain (MRGR3)with its teicoplanin-resistant derivative (14-4).
ORGANISM(S): Staphylococcus aureus 
2007-01-01 | E-MEXP-738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mosquitos fed blood infected with two alternative P. berghei strains: wild type (wt) or an invasion-deficient, CTRP (Circumsporozoite- and TRAP-related protein) knockout (ko) strain
Female mosquitoes fed with blood infected with two alternative P. berghei strains: wild type (wt) or an invasion-deficient, CTRP (Circumsporozoite- and TRAP-related protein) knockout (ko) strain. We used CTRPko-infected midguts as reference, as they experience pre-invasion conditions similar to thos...
ORGANISM(S): Anopheles gambiae 
2005-07-12 | E-MEXP-378 | biostudies-arrayexpress
TranscriptomicsRegulatory role of SrrAB two-component system in Staphylococcus epidermidis growth and biofilm formation
Biofilm formation is considered the most important factor involved in pathogenicity of Staphylococcus epidermidis.We investigated the role of two-component signal transduction system (TCS) srrAB, which was up-regulated under micro-aerobic condition, in the growth and biofilm formation of S. epidermi...
ORGANISM(S): Staphylococcus epidermidis 
2014-11-21 | E-GEOD-47101 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the Staphylococcus aureus response to mupirocin
In the present study we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization of S. aureus. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRSs) leading to the accumulation of uncharged isoleucyl-tRNA and hence (p)ppGpp. The latter is...
ORGANISM(S): Staphylococcus aureus 
2012-01-23 | E-GEOD-30743 | biostudies-arrayexpress
TranscriptomicsGdpS contributes to Staphylococcus aureus biofilm formation by regulation of eDNA release
In Staphylococcus aureus, the role of the GGDEF domain containing protein GdpS remains poorly understood. Previous studies reported that gdpS mutant strains had decreased biofilm formation due to changes in icaADBC expression that were independent of cyclic-di-GMP levels. We deleted gdpS in three un...
ORGANISM(S): Staphylococcus aureus 
2014-06-30 | E-GEOD-48656 | biostudies-arrayexpress
TranscriptomicsBacillithiol as Part of the Response of Staphylococcus aureus to Oxidative Stress
Overnight cultures of wild type COL or the bshA mutant were back-diluted to an O.D.650 of 0.1 in 30 mL of TSB. The cells were grown at 37C with shaking in a 300mL flask until they reached an O.D.650 of 1.1. The cells were then equally separated into 50mL Falcon tubes, so that each tube had 10mL of c...
ORGANISM(S): Staphylococcus aureus subsp. aureus COL 
2013-11-12 | E-GEOD-46885 | biostudies-arrayexpress
UnknownGenetic architecture of acute hyperthermia resistance in juvenile rainbow trout (Oncorhynchus mykiss) and genetic correlations with production traits.
Not available
S-EPMC10259007 | biostudies-literature
TranscriptomicsMicroarray analysis of microbiota of gingival lesions in noma patients
We used phylogenetic low-density microarrays targeting the 16S rRNA gene to characterize the gingival flora of acute noma and acute necrotizing gingivitis lesions, and compared them to healthy control subjects of the same geographical and social background. Various types of samples were collected (c...
ORGANISM(S): human oral metagenome 
2013-12-27 | E-GEOD-43612 | biostudies-arrayexpress
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
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