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ProteomicsIntramolecular synergism and proteolytic control of bacteriophage endolysin PlySK1249
Endolysins are peptidoglycan hydrolases produced at the end of the bacteriophage (phage) replication cycle to lyse the host cell. Gram-positive phages endolysins come in a variety of multi-modular forms that combine different catalytic domains and may have evolved to adapt to their bacterial hosts. ...
ORGANISM(S): Streptococcus agalactiae FSL S3-026 Streptococcus dysgalactiae subsp. equisimilis SK1249 
2021-04-15 | PXD024020 | Pride
Endolysin Proteolysis Bacteriophage Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse PERK mutant vs. wild type
Molecular characterization of PERK's role in the mouse exocrine pancreas. Postnatal days 16, 19 and 32 were examined. Postnatal day 16 represents a stage immediately prior to severe cytological changes in the exPKO mice. Postnatal day 19 represents the initial stage of severe phenotypes in the ex...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4422 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cells, pro-B cells and TEL-AML1 tranduced cord blood cells to study TEL-AML1 associated childhood leukemia
The microarray data presented here relate to a study on TEL-AML1 associated childhood leukemia (Hong et al, 2008) the abstract of which is as follows:

"Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framew...
ORGANISM(S): Homo sapiens 
2008-01-20 | E-MEXP-1403 | biostudies-arrayexpress
TranscriptomicsA diverse set of microRNAs and microRNA-like small RNAs in developing rice grains
Endogenous small RNAs, including microRNAs (miRNAs) and short-interfering RNAs (siRNAs), function as posttranscriptional or transcriptional regulators in plants. miRNA function is essential for normal development and therefore likely to be important in the growth of the rice grain. To investigate th...
ORGANISM(S): Oryza sativa 
2008-08-21 | E-GEOD-11014 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiomyocytes (NRVCMs) stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM
Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5996 | biostudies-arrayexpress
TranscriptomicsCircadian clock-mediated transcriptional regulation in maize
The goal of the experiment was to perform a large scale study of circadian regulation of gene expression in maize. To identify maize genes with expression regulated by the circadian clock, transcript levels in the aerial tissues of young maize seedlings were determined by transcriptional profiling w...
ORGANISM(S): Zea mays 
2011-08-30 | E-GEOD-31763 | biostudies-arrayexpress
TranscriptomicsTenascin-C Protects Cancer Stem-Like Cells from Immune Surveillance
Precociously disseminated cancer cells may seed quiescent sites of future metastasis if they can protect themselves from immune surveillance. However, there is little knowledge about how such sites might be achieved. Here we present evidence that prostate cancer stem-like cells (CSC) can be found in...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-65502 | biostudies-arrayexpress
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of control and catalase-deficient Arabidopsis (Arabidopsis thaliana) plants
In plants, reactive oxygen species and, more particularly, hydrogen peroxide (H2O2) play a dual role as toxic by-products of normal cell metabolism and as regulatory molecules in stress perception and signal transduction. Peroxisomal catalases are an important sink for photorespiratory H2O2. Using A...
ORGANISM(S): Arabidopsis thaliana 
2005-10-11 | E-MEXP-449 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast cells grown into stationary phase compared with exponential mid-log grown cells including a dye-swap
S. cerevisiae cells grown into stationary phase were compared with exponential mid-log grown cells including a dye-swap. External normalization controls were added in equal amounts to equivalent amounts of total RNA.
ORGANISM(S): Saccharomyces cerevisiae 
2003-04-01 | E-UMCU-4 | biostudies-arrayexpress
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