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The sperm fusion complex built around the Izumo1 protein is the key male factor for mediation of gamete fusion. Loss of several complex members leads to male infertility. Here, we provide a detailed characterisation of the C11orf94/Frey protein which acts as central chaperone for assembly of the spe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD030545 | Pride
The major human pathogen Staphylococcus aureus possesses ten extracellular proteases that are central to the virulence process. While some host targets of these and other bacterial proteases are known, a major bottleneck to the study of their function is the low-throughout nature of substrate identi...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2021-03-29 | PXD014797 | Pride
This experiment aims to profile polyclonal antibody binding profiles in serum from vaccinated animals relative to antibody function in a virus neutralization assay. Rabbits received three vaccinations with a DNA vaccine encoding the spike protein of the SARS-CoV-2 index strain. Serum samples were se...
ORGANISM(S): Oryctolagus cuniculus 
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