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ProteomicsBioID of the proteins CGP and FRM1 from Toxoplasma gondii
The conoid complex, a unique structure in the phylum Apicomplexa, is crucial for host cell invasion, egress, and motility. Despite its importance, the detailed molecular composition and assembly mechanisms of the conoid complex remain poorly understood. In previous research, we identified an essenti...
ORGANISM(S): Toxoplasma gondii RH 
2025-09-17 | PXD053452 | Pride
Interactor Conoid complex Toxoplasma gondii Cgp Frm1 
ProteomicsEvolutionarily Convergent Mechanism of Formin Regulation Coordinates Actin Polymerization in Apicomplexan Parasites
Apicomplexan parasites rely on actin-based motility for host cell invasion and for their dissemination. Although previous studies implicate formin 1 (FRM1) in governing this process in Toxoplasma, the mechanisms that position it at the cell apex and regulate its activity during the transition from i...
ORGANISM(S): Toxoplasma gondii ME49 
2025-11-04 | PXD068228 | Pride
Methylation Gliding motility Intramolecular regulation Autoinhibition Actin polymerization Formin 
UnknownPlasmodium falciparum formins are essential for invasion and sexual stage development.
Not available
S-EPMC10439200 | biostudies-literature
UnknownEvolutionarily convergent mechanism of formin regulation coordinates actin polymerization in apicomplexan parasites.
Not available
S-EPMC12693976 | biostudies-literature
ProteomicsThe role of methylation in egress and motility initiation in Toxoplasma gondii
Apicomplexan parasites such as Toxoplasma gondii depend on finely tuned cytoskeletal dynamics to invade and exit host cells. A central structure in this process is the conoid, a dynamic apical microtubule-based scaffold that integrates signalling and structural cues to initiate motility. While the l...
ORGANISM(S): Toxoplasma gondii RH 
2026-08-24 | PXD067879 | Pride
Akmt Toxoplasma gondii Motility initiation Apical methylation Pckmt 
UnknownEffect of Neuroprotective Magnesium Sulfate Treatment on Brain Transcription Response to Hypoxia Ischemia in Neonate Mice.
Not available
S-EPMC8074012 | biostudies-literature
TranscriptomicsHippocampus CA1 pyramidal cells Transcriptomic profile in WT and Fmr1 KO mice, using Wfs1-CreERT2:RiboTag:Frm1 knockout and wildtype mice
Comparing WT mice to a mouse model of mental retardation, this work identifies genes which display differences in ribosome-bound mRNAs, in hippocampus CA1 pyramidal cells. These genes products are potent functional components of neuronal plasticity and hippocampus-dependent memory.
ORGANISM(S): Mus musculus 
2017-11-08 | GSE94559 | GEO
UnknownAn apical ring protein essential for conoid complex assembly and daughter cell formation in Toxoplasma gondii.
Not available
S-EPMC12663574 | biostudies-literature
GenomicsMus musculus
Hippocampus CA1 pyramidal cells Transcriptomic profile in WT and Fmr1 KO mice, using Wfs1-CreERT2:RiboTag:Frm1 knockout and wildtype mice
PRJNA371470 | ENA
UnknownThe Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors.
Not available
S-EPMC6225207 | biostudies-literature
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