Sort   by:  
 Page size 
Cotranslational targeting into the endoplasmic reticulum (ER) by the Signal Recognition Particle (SRP) is a key event determining polypeptide fate in eukaryotic cells. Here, we globally define the principles and mechanisms of SRP binding and ER targeting in vivo. Cotranslational targeting through SR...
ORGANISM(S): Saccharomyces cerevisiae 
Protein misfolding is linked to a wide variety of human disease. Protective cellular protein quality control (PQC) mechanisms evolved to selectively recognize misfolded proteins and limit their toxic effects. Using yeast as a model system, we previously discovered that the misfolded protein VHL inte...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-11-04 | PXD010660 | Pride
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine (polyQ) tract. Although mutant HTT (mHTT) protein is known to aggregate, the links between aggregation and neurotoxicity re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-03-13 | PXD026012 | Pride
The goal of this study was to identify yeast mutants with arsenite hypersensitivity. Keywords: dose response Matched pools of yeast knockout (YKO) mutants were grown in paired growth media lacking or containing arsenite at various concentrations. The relative abundances of the YKO mutants were profi...
ORGANISM(S): Saccharomyces cerevisiae 
Sort   by:  
 Page size