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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
ProteomicsDeletion of the mitochondrial peptidase miPEP in adipose tissue protects against obesity and insulin resistance by increasing adaptive thermogenesis
Mitochondria are pivotal for cellular metabolism, serving as sources and targets of nutrient intermediates from converging metabolic pathways. Here, we demonstrate that insulin resistance leads to a marked alteration in the mitochondrial proteome of adipocytes. Analysis across multiple insulin resis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD051606 | Pride
Insulin resistance Mipep Thermogenesis Adipose Mitochondria 
UnknownDynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP.
Not available
S-EPMC7296346 | biostudies-literature
UnknownTop Ten epilepsy research priorities: A UK priority setting partnership.
Not available
S-EPMC7618077 | biostudies-literature
UnknownSynteny - a high throughput web tool to streamline causal gene prioritisation and provide insight into protein function.
Not available
S-EPMC12749926 | biostudies-literature
UnknownBaRTv1.0: an improved barley reference transcript dataset to determine accurate changes in the barley transcriptome using RNA-seq.
Not available
S-EPMC6907147 | biostudies-literature
ProteomicsA novel translocon for biogenesis of multi-pass membrane proteins
A novel 370 kDa translocon comprising Sec61 and five accessory factors acting co-translationally with ribosomes to fold and insert multi-pass membrane proteins was identified, purified and analyzed structurally by single particle cryo-EM and cross-linking mass spectrometry. The purified ribosome-tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-08 | MSV000084065 | MassIVE
UnknownGenetic variance in the murine defensin locus modulates glucose homeostasis.
Not available
S-EPMC12528722 | biostudies-literature
UnknownBaRTv2: a highly resolved barley reference transcriptome for accurate transcript-specific RNA-seq quantification.
Not available
S-EPMC9546494 | biostudies-literature
UnknownTissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis.
Not available
S-EPMC6961418 | biostudies-literature
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