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TranscriptomicsTranscription profiling by array of liver from rats treated with furan to study furan-induced cholangiofibrosis
Male Sprague Dawley Crl CD BR rats (190-240g, 6-8 weeks old), were obtained from Charles River, UK. They were given access to R&M No.1 diet and tap water ad libitum. Animals were housed 5/sex in solid bottom cages maintained at 21oC +/- 2oC, 12 h light and 12 h dark. All animals were acclimatised fo...
ORGANISM(S): Rattus norvegicus 
2008-04-01 | E-MEXP-1421 | biostudies-arrayexpress
TranscriptomicsDNA methylation changes by furan in Sprague Dawley rat liver
We tested the hypothesis that alteration of DNA methylation may contribute to rodent carcinogenicity of furan. Methylated DNA from control and treated samples were immunoprecipitated by anti-MeC. The samples were sent to NimbleGens service laboratory to perform the microarray experiments and data an...
ORGANISM(S): Rattus norvegicus 
2011-06-23 | E-MTAB-716 | biostudies-arrayexpress
TranscriptomicsThe effect of BrdU on gene expression profiles of B6C3F1 mice treated with furan
Furan is a mouse and rat hepatocarcinogen. We sought to determine the dose-dependent changes in gene expression upon exposure of B6C3F1 mice to furan in order to better understand furan’s mode of action. In this study we examined the transcriptional response in liver tissue of female B6C3F1 mice to ...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-54078 | biostudies-arrayexpress
ProteomicsFuran warheads for covalent trapping of weak protein-protein interactions: specific cross-linking of thymosin β4 to actin
We describe furan as a triggerable ‘warhead’ for site-specific cross-linking using the actin and thymosin β4 (Tβ4)-complex as model of a weak and dynamic protein-protein interaction with known 3D structure and with application potential in disease contexts. The presented in vitro validation of coval...
ORGANISM(S): Oryctolagus sp. 'Rabbit_OD' 
2021-05-13 | PXD025066 | Pride
Furan Cross-linked peptide Mass spectrometry Actin Cross-link Thymosin β4 Protein-protein interactions Covalent 
TranscriptomicsCell death and regenerative proliferation pathways in hepatocellular carcinoma: The effect of furan on B6C3F1 mouse global gene expression in liver
Furan is a mouse and rat hepatocarcinogen. We sought to determine the dose-dependent changes in gene expression upon exposure of B6C3F1 mice to furan in order to better understand furan’s mode of action. Adult female B6C3F1 mice were exposed to 1, 2, 4 or 8 mg/kg bw furan or vehicle control (corn oi...
ORGANISM(S): Mus musculus 
2014-01-10 | E-GEOD-48644 | biostudies-arrayexpress
TranscriptomicsToxicogenomic Assessment of Liver Responses following subchronic exposure to furan in Fischer F344 rats [miRNA]
Furan is a widely used industrial chemical and a common contaminant in heated foods. Chronic furan exposure has been shown to cause cholangiocarcinoma and hepatocellular tumors at doses of 2 mg/kg bw/day with gender differences in frequency and severity. The hepatic transcriptional alterations induc...
ORGANISM(S): Rattus norvegicus 
2014-10-30 | E-GEOD-62807 | biostudies-arrayexpress
ProteomicsCell Surface Biotinylation via Furan Crosslinking to Profile the Surfaceome
The cellular surfaceome is crucial for cellular homeostasis and communication, with surface proteins acting as key receptors, transporters, and enzymes. However, comprehensive analysis of the surfaceome is challenging due to the hydrophobic nature and low abundance of membrane proteins, resulting un...
ORGANISM(S): Homo sapiens (Human) 
2025-10-21 | PXD059552 | Pride
Proteomics Affinity purification Furan-biotin Plasma membrane proteins Lc-ms/ms Surfaceome 
TranscriptomicsToxicogenomic Assessment of Liver Responses following subchronic exposure to furan in Fischer F344 rats [cRNA]
Furan is a widely used industrial chemical and a common contaminant in heated foods. Chronic furan exposure has been shown to cause cholangiocarcinoma and hepatocellular tumors at doses of 2 mg/kg bw/day with gender differences in frequency and severity. The hepatic transcriptional alterations induc...
ORGANISM(S): Rattus norvegicus 
2014-10-30 | E-GEOD-62806 | biostudies-arrayexpress
GenomicsEarly microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes
Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes
PRJNA930135 | ENA
TranscriptomicsPersistence of furan-induced epigenetic aberrations in the livers of Fisher 344 rats
Furan is a heterocyclic organic compound produced in the chemical manufacturing industry and also found in a broad range of food products, including infant formulas and baby foods. Previous reports have indicated that the adverse biological effects of furan, including its liver tumorigenicity, may b...
ORGANISM(S): Rattus norvegicus 
2014-12-02 | GSE63740 | GEO
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