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ProteomicsPresentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles
Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in this disease is its highly conserved driver mutation: a gene fusion between DNAJB1 and PRKACA, which is expressed in virtually all FLC tumors and could be a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042316 | Pride
Fusion neoantigens Hla class i Cd8 t cell Dnajb1-prkaca Fibrolamellar carcinoma 
ProteomicsB cell Lymphomas present Immunoglobulin Neoantigens
Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chr...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010808 | Pride
Lymphoma Neoantigens Mhc Orbitrap 
ProteomicsThe GF-NEO Discovery Platform: A Systems-Level Approach to Analyzing and Validating Fusion Neoantigens in Pediatric Cancer
Gene fusions (GFs) are critical events in pediatric oncology, often serving as oncogenic drivers. However, fusion proteins and their derived neoantigens (GF-NEOs) remain underexplored for targeted immunotherapy. We developed ProteoFusioNEO, a computational tool for in silico translation of transcrip...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD063253 | Pride
UnknownThe Landscape of Tumor Fusion Neoantigens: A Pan-Cancer Analysis.
Not available
S-EPMC6838548 | biostudies-literature
UnknownNeoFuse: predicting fusion neoantigens from RNA sequencing data.
Not available
S-EPMC7141848 | biostudies-literature
UnknownIdentification of candidate neoantigens produced by fusion transcripts in human osteosarcomas.
Not available
S-EPMC6344567 | biostudies-literature
ProteomicsImmunopeptidomics guided identification of neoantigens in non-small cell lung cancer
Discovery of tumour specific peptides (neoantigens) generating target specific personalised T cell therapies is difficult because of the complex relationship between genetic mutations and neoantigen presentation. Studies predicting neoantigens have a 5% success rate, and direct observations of neoan...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD028990 | Pride
Cancer Hla Lung Neoantigen Peptidome 
UnknownEndogenous T cell responses to fusion-derived neoantigens in pediatric acute leukemias.
Not available
S-EPMC12463655 | biostudies-literature
ProteomicsIdentification of neoantigens in oesophageal adenocarcinoma
We present data from tissues of seven oesophageal adenocarcinomas of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.This dataset forms part of the publication:Nicholas, B., Bailey, A., McCann, K.J., Wood, O., Walke...
ORGANISM(S): Homo sapiens (Human) 
2022-09-27 | PXD031108 | Pride
Human Oesophageal adenocarcinoma Immunopeptidome Hla 
UnknownThe GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer.
Not available
S-EPMC12818165 | biostudies-literature
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