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ProteomicsChemical cross-linking enables drafting ClpXP proximity maps and taking snapshots of in vivo interaction networks
Protein-protein interactions within complexes and networks are often dynamic and their elucidation remains a challenging task. Here, we show on the example of the proteolytic ClpXP complex the power of combined chemical cross-linking and mass-spectrometry to capture transient binding interactions wi...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Staphylococcus aureus 
2018-11-21 | PXD009224 | Pride
Clpxp Interacting proteins Chemical cross-linking Co-ip Clpp 
ProteomicsBiochemical and proteomic studies on pyridoxal 5'-phosphate-binding protein (PLPBP)
Structural and proteomic investigations on conserved PLPBP.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD015984 | Pride
Prosc Plpbp Pyridoxal 
ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
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