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ProteomicsCharacterizations of G-quadruplex RNA-Protein Interactions in Living Cells
RNA guanine quadruplexes (rG4s) are non-canonical nucleic acid structures essential for various cellular functions and disease pathways. Characterizing rG4-interacting proteins (rG4IPs) is crucial for deciphering biological roles of rG4s. Building upon the RNA-protein interaction detection (RaPID) m...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD070623 | Pride
G-quadruplex Rna-protein interactions Proteomics Lc-ms/ms 
GenomicsG-Quadruplex structural motifs modulate protein-RNA interactions within the transcriptome
G-Quadruplex structural motifs modulate protein-RNA interactions within the transcriptome
PRJNA1198313 | ENA
GenomicsCharacterizations of G-quadruplex RNA-Protein Interactions in Living Cells
Characterizations of G-quadruplex RNA-Protein Interactions in Living Cells
PRJNA1377449 | ENA
ProteomicsComprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5’ UTR of tumor-associated mRNAs
G-quadruplex structures in the 5’ UTR of mRNAs are widely considered to suppress translation without affecting transcription. The current study describes the comprehensive analysis of proteins binding to four different G-quadruplex motifs located in mRNAs of the cancer-related genes Bcl-2, NRAS, MMP...
ORGANISM(S): Homo sapiens (Human) 
2017-11-14 | PXD005761 | Pride
Nras Cancer Translational regulation Silac Mmp16 Rna Rbps Shotgun proteomics G-quadruplexes Bcl-2 Arpc2 Post-transcriptional regulation 
ProteomicsNon-canonical RNA-binding of the histone lysine demethylase KDM5 through interactions with G-quadruplex sequences
RNA-binding proteins are important regulators of RNA biogenesis and function, and recent work shows that chromatin- and RNA-binding proteins can have regulatory roles in transcription. Several approaches have been developed to predict RNA-binding proteins and to identify them experimentally at large...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD050767 | Pride
Histone lysine demethylase kdm5  g-quadruplex  non-canonical rna-binding 
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
UnknownSpecific suppression of D-RNA G-quadruplex-protein interaction with an L-RNA aptamer.
Not available
S-EPMC7544233 | biostudies-literature
UnknownDeciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences.
Not available
S-EPMC12673844 | biostudies-literature
UnknownAn intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.
Not available
S-EPMC3528108 | biostudies-literature
GenomicsA proteomics screen uncovers CTCF as a key G-quadruplex binding protein [RNA-seq]
A proteomics screen uncovers CTCF as a key G-quadruplex binding protein [RNA-seq]
PRJNA1217454 | ENA
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