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GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
GenomicsRNA G-quadruplex secondary structure promotes alternative splicing via the RNA binding protein hnRNPF
RNA G-quadruplex secondary structure promotes alternative splicing via the RNA binding protein hnRNPF
PRJNA420499 | ENA
GenomicsG-quadruplex DNA structure is a positive regulator of MYC transcription
G-quadruplex DNA structure is a positive regulator of MYC transcription
PRJNA925884 | ENA
ProteomicsMultistep mechanism of G-quadruplex resolution during DNA replication
G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that a...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-17 | PXD027623 | Pride
G4 resolution G-quadruplex Helicases Dhx36 G4 Fancj Dna replication 
GenomicsProfiling DNA G-quadruplex structures at single-cell level
Profiling DNA G-quadruplex structures at single-cell level
PRJNA751854 | ENA
GenomicsIdentification of G-quadruplex clusters by high-throughput sequencing of whole genome amplified products with G-quadruplex ligand
Identification of G-quadruplex clusters by high-throughput sequencing of whole genome amplified products with G-quadruplex ligand
PRJNA1273212 | ENA
TranscriptomicsRNA G-quadruplex secondary structure promotes alternative splicing via the RNA binding protein hnRNPF
It is generally thought that splicing factors regulate alternative splicing through binding to RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is emerging as an important layer in splicing regulation. Here we demonstrate that RNA elements with G-quadruplex formin...
ORGANISM(S): Homo sapiens 
2018-01-22 | GSE107542 | GEO
GenomicsG-quadruplex structures moulds the DNA methylome
G-quadruplex structures moulds the DNA methylome
PRJNA421087 | ENA
GenomicsAn Upstream G‐Quadruplex DNA Structure Can Stimulate Gene Transcription
An Upstream G‐Quadruplex DNA Structure Can Stimulate Gene Transcription
PRJNA1006033 | ENA
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