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ProteomicsStochiometric Quantification of the Thiol Redox Proteome Reveals Subcellular Compartmentalization and Susceptibility to Oxidative Perturbations
Posttranslational modifications of protein cysteine thiols play a significant role in redox regulation and the pathogenesis of human diseases. However, the cellular redox landscape in terms of quantitative, site-specific occupancies of thiol modifications at the proteome level, especially under phys...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-13 | PXD019913 | Pride
Site-occupancy Macrophage Resin-assisted enrichment Redox proteomics S-glutathionylation Stoichiometry Redox modification Protein thiols 
ProteomicsLate-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Redox proteomic data from the heart of young mice, old mice, or mice treated with SS31. Quantification of protein-S-glutathionylation was performed using an established redox proteomics workflow. LC-MS/MS raw data were searched with MS-GF+ against the mouse protein sequence database from the Uniprot...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-04-23 | MSV000085329 | MassIVE
ProteomicsNanowell-Mediated Two-Dimensional Liquid Chromatography Proteome Profiling of Mammalian Cells
Proteomic data from technical developments of a nanowell-mediated two-dimensional (2D) reversed-phase nanoflow liquid chromatography (LC) separation for in-depth proteome profiling of low-nanogram samples.
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD010150 | Pride
Proteomics Microfluidics 2d lc 
ProteomicsIn-depth proteome profiling of small extracellular vesicles isolated from cancer cell lines and patient serum
Extracellular Vesicle (EV) secretion has been observed from most types of normal and tumor cells. These EVs contain a variety of distinctive cargo where tumor-derived serum proteins in EVs secreted into the bloodstream can be used to provide a minimally invasive method for clinical monitoring. We ha...
ORGANISM(S): Homo Sapiens (human) 
2024-09-08 | PXD045198 | JPOST Repository
ProteomicsMass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress
A 2D-LC-MS/MS strategy coupled with TMT-10 labeling was applied to mouse pancreatic beta cells (hetaTC-6) induced with ER stress by Thapsigargin to study the global proteome and protein cysteine PTM changes under ER stress. Samples were digested with trypsin, labeled with 10-plex TMT, then analyzed ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-05-29 | MSV000087543 | MassIVE
ProteomicsRegulation of hyperoxia-induced neonatal lung injury via posttranslational cysteine redox modifications
Lung tissue from normoxia- or hyperoxia-treated control or SCNN1B overexpression mice were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-18 | MSV000090157 | MassIVE
ProteomicsAn Integrative SP3 Workflow for Multi-PTM Proteomics Profiling
Global proteomic, redox proteomic, and phosphoproteomic data from mouse C10 epithelial cells and skeletal muscle tissue, no treatments used for method development experiments using these biological sytems. Global proteomic, redox proteomic, phosphoproteomic, and acetylomic data from mouse Beta-TC-6 ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-06 | MSV000095264 | MassIVE
ProteomicsAutomated coupling of nanodroplet sample preparation with liquid chromatography-mass spectrometry for high throughput single-cell proteomics
Development and evaluation of an autosampler for integrating nanoPOTS with LC-MS. Includes proteomic data from nanoPOTS-based sample preparation, including diluted peptides of Shewanella oneidensis MR-1, single cultured MCF10A cells, and single cells from three Acute Myeloid Leukemia (AML) cell line...
ORGANISM(S): Shewanella Oneidensis Mr-1 (ncbitaxon:211586) Homo Sapiens (ncbitaxon:9606) 
2020-04-05 | MSV000085230 | MassIVE
ProteomicsSignatures of Cysteine Oxidation on Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults
Human muscle biopsies from older adults were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-17 | MSV000093136 | MassIVE
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