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TranscriptomicsTranscription profiling of hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia
Hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice were subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia.
ORGANISM(S): Mus musculus 
2005-12-31 | E-MEXP-496 | biostudies-arrayexpress
TranscriptomicsAltered Epigenetic Regulation of Homeobox Genes in Human Oral Squamous Cell Carcinoma Cells
To gain insight into the molecular changes during OSCC carcinogenesis, we performed unbiased, whole genome deep sequencing (RNA-seq) using RNA isolated from cultured, human TERT-immortalized, non-tumorigenic OKF6-TERT1R and OSCC SCC-9 cells. OKF6-TERT1R cells and SCC-9 cells were plated in 10 cm2 t...
ORGANISM(S): Homo sapiens 
2013-10-19 | E-GEOD-51415 | biostudies-arrayexpress
MetabolomicsSuboxic DOM is bioavailable to surface prokaryotes in a simulated overturn of an oxygen minimum zone, Devil’s Hole, Bermuda
Oxygen minimum zones (OMZs) are expanding due to increased sea surface temperatures, subsequent increased oxygen demand through respiration, reduced oxygen solubility, and thermal stratification driven in part by anthropogenic climate change. Devil's Hole, Bermuda is a model ecosystem to study OMZ m...
2024-02-27 | MTBLS8122 | MetaboLights
ProteomicsThe E3 ligase TRIM25 impairs apoptotic cell death in colon carcinoma cells through hnRNPH1-triggered destabilization of caspase-7 mRNA
Therapy resistance is still a major reason for treatment failure in colorectal cancer (CRC). Previously, we identified the E3 ubiquitin ligase TRIM25 as a novel suppressor of caspase-2 translation, thereby contributing to apoptosis resistance of CRC cells towards chemotherapeutic drugs. We herein re...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD037182 | Pride
Trim25 Colon carcinoma cells Caspase-7 Hnrnph1 Rna binding proteins Apoptosis 
ProteomicsExposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome inhibiting protein synthesis and reducing virulence
The antimicrobial properties of silver have been exploited for many centuries and continue to gain interest in the fight against antimicrobial drug resistance. The broad-spectrum activity and low toxicity of silver has led to its incorporation into a wide range of novel antimicrobial agents, includi...
ORGANISM(S): Candida parapsilosis CDC317 
2022-06-28 | PXD025693 | Pride
Antimicrobial Silver Proteomics Candida 
TranscriptomicsForkhead Box F1 (FOXF1) represses fibroblast functions relevant to fibrogenesis
Aberrant expression of master phenotype regulators by lung fibroblasts may play a central role in idiopathic pulmonary fibrosis (IPF). Interrogating IPF fibroblast transcriptome datasets, we identified Forkhead Box F1 (FOXF1), a DNA-binding protein required for lung development, as a candidate actor...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-52612 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human polymorphonuclear leukocytes (PMNs) from healthy individuals vs patients with X-linked chronic granulomatous disease
Polymorphonuclear leukocytes (PMNs) were obtained from healthy individuals (Healthy1, Healthy2, Healthy3, and Healthy4) or patients with X-linked chronic granulomatous disease (XCGD1, XCGD2, XCGD3, XCGD4, XCGD5, and XCGD6). The studies were performed in accordance with a protocol approved by the Ins...
ORGANISM(S): Homo sapiens 
2007-09-29 | E-GEOD-935 | biostudies-arrayexpress
UnknownPhase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.
Not available
S-EPMC3532390 | biostudies-literature
TranscriptomicsGeneration and purification of Th1 and Th2 effector and memory CD4+ T cells
Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress
ProteomicsComprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C—H Functionalization
The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and investigating its mechanism of action have been hinde...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024455 | Pride
Competitive pull-down Multi-probe proteomics Leukemia stem cells C-h functionalization Biocatalysis Sesquiterpene lactones 
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