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TranscriptomicsGene expression in Galectin-3 KO vs. WT CD8 T cells
The goal of this study was to examine differences in gene expression of tumor specific CD8 T cells in an in vivo tumor mouse model after inhibition of galectin-3 protein expression by genetic knockout. Galectin-3 is thought to modulate CD8 T cell response by cross-linking cell surface glycoproteins...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-59454 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived dendritric cells matured with Galectin-1 or LPS vs controls
Human monocyte derived dendritic cells matured via galectin-1 or LPS. Experiment Overall Design: 4 conditions with 3 replicates of each include control or intreated immature MDDCS, galectin-1 treated MDDCs, LPS treated MDDCs, and vehicle control MDDCs. (each replicate is from a distinct DONOR). Dend...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4984 | biostudies-arrayexpress
ProteomicsGalectin-1 and Galectin-3 interactors
Identification of interactors is a major attempt in cell biology. Not only protein-protein but also protein-carbohydrate interactions are of high relevance for signal transduction in biological systems. Here we aim to identify novel interacting binding partners for the β-galactoside-binding proteins...
ORGANISM(S): Homo sapiens (Human) 
2017-06-06 | PXD005461 | Pride
Interactors Galectin Pull-down Retina 
TranscriptomicsGalectin-3 regulates the expression of various genes in human gastric cancer cells
Although galectin-3 is known to modulate the cell proliferation, RNA processing, tumorigenesis, metastasis and apoptosis and also, which is highly expressed in human cancers, the function of galectin-3 is still controversy in gastric cancer. Here, we demonstrated the function of galectin-3 on gastri...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-29630 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human head and neck squamous cell carcinoma to study the correlation between galectin-1 upregulation and the presence of SMA positive cancer-associated fibroblasts
In this study, we set the presence of smooth muscle actin (SMA)-positive cancer-associated fibroblasts (CAFs) in relation to galectin-1 and its in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence is highly significantly correlated to pre...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-MTAB-850 | biostudies-arrayexpress
ProteomicsQuantitative proteomic study of two cervical cancer cell lines upon re-expression of Galectin 7
Galectin-7 expression was found to be strongly reduced in cervical cancer cell lines. The same tumor cell lines in which Galectin-7 was ectopically expressed exhibited significant decrease in their tumorigenic capacity in vitro and in vivo. The proteomic changes in the cervical cancer cell lines HeL...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080855 | MassIVE
ProteomicsMUSCLE-DERIVED GALECTIN 3 IS A NEW MEDIATOR OF MUSCLE TO BONE CROSSTALK
Galectin-3 is a pleiotropic lectin that regulates multiple cellular processes in a multitude of tissue types. In bone, depending on its cellular localization, Galectin 3 has a dual and opposite role, as if on the one hand intracellular Galectin 3 promotes bone formation, on the other circulating Gal...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040187 | Pride
Muscle to bone crosstalk Galectin 3 Proteomics Bone remodeling 
ProteomicsMapping glycan-mediated galectin-3 interactions by live cell proximity labeling
Galectin-3 is a glycan-binding protein (GBP) that binds β -galactoside glycan structures to orchestrate a variety of important biological events, including the activation of hepatic stellate cells and regulating immunological responses. While the requisite glycan epitopes needed to bind galectin-3 h...
ORGANISM(S): Homo sapiens (Human) 
2021-06-16 | PXD021622 | Pride
Proteomics Galectins Proximity labeling 
TranscriptomicsGalectin-3 interacts with components of the nuclear ribonucleoprotein complex
The multifunctional -galactoside-binding protein galectin-3 is found in many distinct subcellular compartments including the cell nucleus. Expression and distribution of galectin-3 between the cell nucleus and the cytosol changes during cell differentiation and cancer development. Nuclear functions ...
ORGANISM(S): Homo sapiens 
2016-06-07 | E-MTAB-4783 | biostudies-arrayexpress
ProteomicsNutrient Responsive O-GlcNAcylation Dynamically Modulates Galectin 3 Secretion
Endomembrane glycosylation and cytoplasmic O-GlcNAcylation each play essential roles in nutrient sensing, and in fact, characteristic changes in glycan patterns have been described in disease states such as diabetes and cancer. These changes in glycosylation have important functional roles and can d...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD028139 | Pride
Hela Gal-3ip 
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