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TranscriptomicsGene expression in Galectin-3 KO vs. WT CD8 T cells
The goal of this study was to examine differences in gene expression of tumor specific CD8 T cells in an in vivo tumor mouse model after inhibition of galectin-3 protein expression by genetic knockout. Galectin-3 is thought to modulate CD8 T cell response by cross-linking cell surface glycoproteins...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-59454 | biostudies-arrayexpress
TranscriptomicsGalectin-3 regulates the expression of various genes in human gastric cancer cells
Although galectin-3 is known to modulate the cell proliferation, RNA processing, tumorigenesis, metastasis and apoptosis and also, which is highly expressed in human cancers, the function of galectin-3 is still controversy in gastric cancer. Here, we demonstrated the function of galectin-3 on gastri...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-29630 | biostudies-arrayexpress
ProteomicsMapping glycan-mediated galectin-3 interactions by live cell proximity labeling
Galectin-3 is a glycan-binding protein (GBP) that binds β -galactoside glycan structures to orchestrate a variety of important biological events, including the activation of hepatic stellate cells and regulating immunological responses. While the requisite glycan epitopes needed to bind galectin-3 h...
ORGANISM(S): Homo sapiens (Human) 
2021-06-16 | PXD021622 | Pride
Proteomics Galectins Proximity labeling 
ProteomicsNutrient Responsive O-GlcNAcylation Dynamically Modulates Galectin 3 Secretion
Endomembrane glycosylation and cytoplasmic O-GlcNAcylation each play essential roles in nutrient sensing, and in fact, characteristic changes in glycan patterns have been described in disease states such as diabetes and cancer. These changes in glycosylation have important functional roles and can d...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD028139 | Pride
Hela Gal-3ip 
TranscriptomicsGalectin-3 interacts with components of the nuclear ribonucleoprotein complex
The multifunctional -galactoside-binding protein galectin-3 is found in many distinct subcellular compartments including the cell nucleus. Expression and distribution of galectin-3 between the cell nucleus and the cytosol changes during cell differentiation and cancer development. Nuclear functions ...
ORGANISM(S): Homo sapiens 
2016-06-07 | E-MTAB-4783 | biostudies-arrayexpress
ProteomicsMUSCLE-DERIVED GALECTIN 3 IS A NEW MEDIATOR OF MUSCLE TO BONE CROSSTALK
Galectin-3 is a pleiotropic lectin that regulates multiple cellular processes in a multitude of tissue types. In bone, depending on its cellular localization, Galectin 3 has a dual and opposite role, as if on the one hand intracellular Galectin 3 promotes bone formation, on the other circulating Gal...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040187 | Pride
Muscle to bone crosstalk Galectin 3 Proteomics Bone remodeling 
ProteomicsGalectin-1 and Galectin-3 interactors
Identification of interactors is a major attempt in cell biology. Not only protein-protein but also protein-carbohydrate interactions are of high relevance for signal transduction in biological systems. Here we aim to identify novel interacting binding partners for the β-galactoside-binding proteins...
ORGANISM(S): Homo sapiens (Human) 
2017-06-06 | PXD005461 | Pride
Interactors Galectin Pull-down Retina 
ProteomicsGalectin-3 binds isoform- and glycoform-specific lacritin in tear fluid
Galectin-3 (Gal-3) is a carbohydrate-binding protein which plays crucial roles in inflammation, immune response, cell migration, autophagy, and signaling. At the ocular surface, Gal-3 is also known to crosslink transmembrane mucins across the epithelial cell glycocalyx, forming lattice structures im...
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD071066 | Pride
Lc-ms/ms Galectin-3 Tear fluid 
TranscriptomicsGene expression change induced by TIM-3/galectin-9 interaction in primary AML
Analysis of gene expression change after galectin-9 stimulation in primary CD34+TIM-3+ AML cells Total RNA obtained from purified CD34+TIM-3+ primary AML cells with or without recombinant human galectin-9 stimulation (20hrs) was subjected to transcriptome analysis
ORGANISM(S): Homo sapiens 
2014-10-10 | E-GEOD-62223 | biostudies-arrayexpress
ProteomicsDynamic N-glycan rearrangement nucleates galectin-3 oligomers and drives endocytosis
Membrane glycoproteins often adopt different conformations when shifting between active and inactive states. Here, we discover a molecular switch that operates through major changes in the spatial arrangement of the N-glycan landscape during such conformational transitions. We demonstrate that the c...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2025-11-10 | PXD041522 | Pride
Cross-link Glycoprotein Structural 
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