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The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of ly...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031543 | Pride
Co-precipitated proteins from REG1CP RNA pull-down assay were separated by 12.5% SDS-PAGE and visualized by silver staining. The specific proteins associated with REG1CP were identified using liquid chromatography-tandem mass spectrometry (LC/MS). The MASCOT database search was applied to validate t...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD015608 | Pride
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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