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ProteomicsEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed on a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteostasis and cell function. The UPR is initiated...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD022554 | Pride
Xbp1 Huntington`s disease Atf6 Upr Parkinson`s disease Er stress Protein aggregation 
UnknownOligometastatic disease, the curative challenge in radiation oncology.
Not available
S-EPMC4530375 | biostudies-literature
TranscriptomicsmiRNA profiles in unstimulated and TLR stimulated MDMs
Macrophages play a crucial role in HIV-1 pathogenesis. Toll-like receptors (TLRs) are fundamental for innate and adaptive immune responses, but their role in HIV-1 infection is still incompletely understood. The TLR3 and TLR4 ligands poly(I:C) and LPS are known to modulate HIV-1 infection of and rep...
ORGANISM(S): Homo sapiens 
2011-12-14 | E-GEOD-34428 | biostudies-arrayexpress
UnknownDesigning a Person-Centred Integrated Care Programme for People with Complex Chronic Conditions: A Case Study from Catalonia.
Not available
S-EPMC8622001 | biostudies-literature
TranscriptomicsGene signature predictive of response to chemotherapy in mCRC [RT-PCR]
The objective is to generate a robust and validated predictor profile for chemotherapy response in patients with mCRC using microarray gene expression profiles of primary colorectal cancer tissue. To define a gene signature of response to chemotherapy in metastatic colorectal cancer, samples were ob...
ORGANISM(S): Homo sapiens 
2013-11-20 | E-GEOD-52513 | biostudies-arrayexpress
Transcriptomicsgene mapping in the physical map of the Triticum aestivum chromosome arm 1BS
To improve our understanding of the organization and evolution of the wheat gene space, we established the first map of genes of the wheat chromosome 1BS by hybridizing the newly developed INRA GDEC Triticum aestivum NimbleGen 12x40k unigenes microarray (A-MEXP-2314) with 3D-pools of MTP BACs of fro...
ORGANISM(S): Triticum aestivum 
2013-12-06 | E-MTAB-1912 | biostudies-arrayexpress
TranscriptomicsApplication of array-CGH for the detection of genomic rearrangements responsible for syndromic mental retardation of unknown cause
Here we describe an interstitial pure duplication of 19p13.3 that was initially considered as a de novo alteration, in a patient with intellectual disability studied by array-CGH. The finding of the same chromosomal alteration in a first-degree cousin of this patient led us to investigate the presen...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-57899 | biostudies-arrayexpress
TranscriptomicsMapping of the HUWE1 duplication at Xp11.22 in eight unrelated XLID patients
In a study to elucidate the genetic defects in patients with X-linked intellectual disability (XLID) we performed X chromosome-specific BAC-array-CGH and identified 0.33 to 1.0 Mb nonrecurrent copy number gains at Xp11.22 in affected males of unrelated XLID families. All aberrations segregate with t...
ORGANISM(S): Homo sapiens 
2012-09-03 | E-GEOD-32945 | biostudies-arrayexpress
TranscriptomicsTranscription map of wheat chromosome 3B
To improve our understanding of the organization and regulation of the wheat gene space, we established the first transcription map of a wheat chromosome (3B) by hybridizing the newly developed INRA GDEC Triticum aestivum NimbleGen 12x40k unigenes microarray with BAC pools from a new version of the ...
ORGANISM(S): Triticum aestivum 
2011-11-03 | E-TABM-1095 | biostudies-arrayexpress
UnknownEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
Not available
S-EPMC8116614 | biostudies-literature
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