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MetabolomicsStudy on Structural Modification of Panaxadiol and Its Anti-Gastric Cancer Activity
In this study, untargeted metabolomic sequencing was performed to investigate the metabolic alterations induced by protopanaxadiol derivatives in gastric cancer cells. All cellular samples were collected from control and treatment groups to explore differentially expressed metabolites and key metabo...
2026-08-03 | MTBLS15239 | MetaboLights
MetabolomicsABCA1-mediated cholesterol transfer in gastric cancer immunity
This study investigates how ABCA1-mediated cholesterol transfer from gastric cancer cells affects the antitumor function of human Vgamma9Vdelta2 T cells. It examines the relationship between cholesterol accumulation, NF-kappaB signaling, and T-cell effector function, and evaluates whether targeting ...
2026-10-21 | MTBLS16098 | MetaboLights
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
MetabolomicsN6-methyladenosine–modified circSLTM inhibits gastric cancer cell proliferation and promotes ferroptosis via interaction with HSPA8

Circular RNAs (circRNAs) are dysregulated in cancers, with N6-methyladenosine (m⁶A)-modified species acting as key regulators of ferroptosis via iron metabolism and lipid peroxidation. This study examines the role of circSLTM (circ-0000605) in gastric cancer (GC). Clinical analyses of GEO data an...

2026-01-16 | MTBLS13702 | MetaboLights
MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
TranscriptomicsExpression data from Helicobacter pylori isolates infecting a gastric epithelial progenitor cell line
Helicobacter pylori clinical isolates can establish themselves in gastric epithelial stem cells and this interaction may have implications for gastric tumorigenesis. Mouse gastric epithelial progenitor cells (mGEPs) were infected for 24hrs with Helicobacter pylori clinical isolates Kx1 and Kx2. Kx1 ...
ORGANISM(S): Helicobacter pylori 
2010-05-26 | E-GEOD-10261 | biostudies-arrayexpress
MetabolomicsPromoting of microplastic intake on gastric epithelial cell carcinogenesis and its molecular mechanism.

The core objective of this study is to clarify the promoting effect of oral ingestion of microplastics on gastric epithelial cell carcinogenesis, systematically decipher the underlying molecular regulatory mechanisms, focus on investigating the key molecular targets involved in oxidative stress i...

2026-01-06 | MTBLS13588 | MetaboLights
MetabolomicsHistone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights
TranscriptomicsEpigenetic analysis of gastric cancer cell lines
Genome wide DNA methylation profiling of gastric cancer cell lines. The Illumina Goldengate DNA methylation Beadchip was used to obtain DNA methylation profiles across 1,505 CpG CpGs in 20 gastric cancer cell lines. Bisulphite converted DNA from the 20 gastric cancer cell lines were hybridised to th...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-29499 | biostudies-arrayexpress
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