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ProteomicsMetabolic modulation of tumors with engineered bacteria for immunotherapy
The availability of L-arginine in tumors is a key determinant of an efficient anti-tumor T cell response. Consequently, elevation of typically low L-arginine levels within the tumor may greatly potentiate the anti-tumor responses of immune checkpoint inhibitors, such as PD-L1 blocking antibodies. H...
ORGANISM(S): Escherichia coli 
2021-07-13 | PXD027167 | Pride
Cancer immunotherapy L-arginine Synthetic biology Metabolic modulation of tumors Bacteria-based therapies 
UnknownIs there pseudoprogression in secondary glioblastomas?
Not available
S-EPMC4349215 | biostudies-literature
ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
UnknownThe unfolded protein response affects readthrough of premature termination codons.
Not available
S-EPMC4023889 | biostudies-literature
UnknownImaging-Detected Extranodal Extension in p16-Positive Oropharyngeal Cancer: Secondary Analysis of RTOG 1016.
Not available
S-EPMC13522994 | biostudies-literature
ProteomicsIdentifying protein interactors of circACVR2A(2-4) in human cells
Differentiation of stem cells is driven by tightly coordinated transcriptional programs, yet the contribution of circular RNAs (circRNAs) to lineage specification remains poorly defined. We identified that depletion of circACVR2A(2–4), but not its linear counterpart, rapidly induced neuroectodermal ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD080807 | Pride
Human Lc-msms Stem cell Circular rna Cyclin h 
UnknownSelf-Perceived Hearing Outcomes With Radiation and Cisplatin or Radiation and Cetuximab for Patients With Human Papilloma Virus (HPV)-Positive Oropharyngeal Cancer-Results From NRG Oncology RTOG 1016.
Not available
S-EPMC12637033 | biostudies-literature
UnknownNiche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.
Not available
S-EPMC5206491 | biostudies-literature
UnknownSerial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation.
Not available
S-EPMC5571807 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
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