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MetabolomicsGut Microbiota Contributes to Heat Tolerance Through Metabolic Remodeling and Suppression of Thermogenesis in Chickens
Background The gut microbiota is increasingly recognized as a key regulator of host metabolic adaptation to environmental challenges. However, whether breed-specific gut microbiota contributes to variation in heat tolerance among poultry breeds remains unclear. This study used Cyan-shank partridge c...
2026-06-18 | MTBLS14785 | MetaboLights
TranscriptomicsYeast (Saccharomyces cerevisiae) Overexpression suppression study
To address the mechanisms of suppression, we analyzed time course of mRNA expression of four suppressed smc2-8 mutant strains. We addressed the question of genomic robustness by systematically screening genomic open reading frames, when induced for high-level expression, for their ability to suppres...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-20 | E-GEOD-24266 | biostudies-arrayexpress
UnknownRobust Filtering and Noise Suppression in Intragenic miRNA-Mediated Host Regulation.
Not available
S-EPMC7554026 | biostudies-literature
MetabolomicsSeed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit
Rice (Oryza sativa L.) is a candidate crop for production of plant-based vaccines by genetic engineering technologies. MucoRice-CTB has been developed as a rice-seed-based vaccine against cholera by transgenic expression of modified cholera toxin B-subunit (CTB) under the RNA interference (RNAi)-med...
2017-08-30 | MTBLS437 | MetaboLights
TranscriptomicsProstate Cancer Gene Expression Changes with Neoadjuvant Hormone Therapy
Men with clinically localized prostate cancer were treated with 0 to 9 months of neoadjuvant hormone suppression prior to prostatectomy. Keywords: microarray, hormone, 9 men with prostate cancer were assigned to neoadjuvant hormone suppression therapy for 3-6, 6, or 0 months.
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9983 | biostudies-arrayexpress
TranscriptomicsIdentification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15440 | biostudies-arrayexpress
ProteomicsPhosphorylation of RXRa mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome
The cJun NH2-terminal kinase (JNK) signaling pathway in the liver promotes systemic changes in metabolism by regulating PPARa-dependent expression of the hepatokine FGF21. Hepatocyte-specific gene ablation studies demonstrated that the Mapk9 gene (encodes JNK2) plays a key mechanistic role. Mutually...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD034183 | Pride
Metabolism Fgf21 Rxr Jnk Liver Phosphorylation 
UnknownSingle-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription.
Not available
S-EPMC4656089 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
TranscriptomicsTissue-specific expression profiles in L. vannamei
RNA from different tissues of Litopenaeus vannamei was used to test the ability of the microarray to discriminate tissue-specific gene expression profiles Keywords: validation, tissue comparison RNA from circulating hemocytes, gills, hepatopancreas, or muscle (3 biological replicates each) was hybri...
ORGANISM(S): Litopenaeus vannamei 
2010-07-01 | E-GEOD-4949 | biostudies-arrayexpress
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