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MetabolomicsIdentification of RXR Ligands
Not available
ORGANISM(S): Mus musculus 
ST000890 | MetabolomicsWorkbench
GenomicsGenome-wide profiling of PPAR?:RXR and RNA polymerase II
Genome-wide profiling of PPAR?:RXR and RNA polymerase II reveals temporal activation of distinct metabolic pathways in RXR dimer composition during adipogenesis. Chromatin immunoprecipitation combined with deep sequencing was performed to generate genome-wide maps of peroxisome prolifelator-activat...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-13511 | biostudies-arrayexpress
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
ProteomicsMolecular determinant for MED1 interaction with the VDR-RXR heterodimer
To provide structural insights into the mechanism of the specific association of the coactivator MED1 with the Vitamin D nuclear (VDR)-RXR heterodimer, we used combined structural methods including X-ray crystallography, small angle X-ray scattering (SAXS), NMR, hydrogen-deuterium exchange coupled t...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD019530 | Pride
Nuclear receptor Vdr-rxr Xl-ms Hdx-ms 
GenomicsRetinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling [RXR and PPARg]
Data from nuclear receptors RXR and PPARg binding to the genome was visualized using Genome Browser (UCSC) in order to test their role in Mafb transcriptional regulation RXR and PPARg ChIP was performed in thioglycollate-elicited peritoneal macrophages in basal conditions
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-63696 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of genes regulated by RXR and its partners in monocyte-derived dendritic cells
CD14+ human monocytes differentiating into DCs in the presence of IL4 and GM-CSF were treated with agonists for RXR and its partners or vehicle 18 hours after plating (experiment with RXR and permissive partners, donor 1-3) or 14 hours after plating (experiment with nonpermissive partners, donor 4-6...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-23073 | biostudies-arrayexpress
ProteomicsStructural basis for DNA recognition and allosteric control of the Retinoic Acid Receptors RAR-RXR
Retinoic Acid Receptors (RARs) as a functional heterodimer with Retinoid X Receptors (RXRs), bind a diverse series of RA-response elements (RAREs) in regulated genes. Among them, the non-canonical DR0 elements are bound by RXR-RAR with comparable affinities to DR5 elements but DR0 elements do not ac...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-10 | PXD018172 | Pride
Hdx Nuclear receptors Structural ms Hdx-ms 
TranscriptomicsExpression data from transgenic mice overexpressing RXR-gamma in the skeletal muscle (RXR-gamma mice)
Retinoid X receptor (RXR)-gamma is a nuclear receptor-type transcription factor expressed mostly in the skeletal muscle, and regulated by nutritional conditions. Previously, we established transgenic mice overexpressing RXR-gamma in the skeletal muscle (RXR-gamma mice), which showed lower blood gluc...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-28447 | biostudies-arrayexpress
GenomicsRAR/RXR binding dynamics distinguishes pluripotency from differentiation-associated cis-regulatory elements
In mouse embryonic cells, a retinoic acid (RA) stimulation triggers a massive change of gene expression leading the pluripotent, proliferating cells to a lineage-specific differentiation process. The retinoic acid receptor (RAR) plays a key role in this response by inhibiting pluripotency-maintainin...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-56893 | biostudies-arrayexpress
TranscriptomicsEffects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin
Examination of three retinoid X receptor (RXR) agonists [Targretin (TRG), UAB30, and 4-methyl-UAB30 (4-Me-UAB30)] showed that all inhibited mammary cancer in rodents and two (TRG and 4-Me-UAB30) strikingly increased serum triglyceride levels. Agents were administered in diets to female Sprague-Dawle...
ORGANISM(S): Rattus norvegicus 
2014-05-14 | E-GEOD-57638 | biostudies-arrayexpress
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