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ProteomicsMolecular determinant for MED1 interaction with the VDR-RXR heterodimer
To provide structural insights into the mechanism of the specific association of the coactivator MED1 with the Vitamin D nuclear (VDR)-RXR heterodimer, we used combined structural methods including X-ray crystallography, small angle X-ray scattering (SAXS), NMR, hydrogen-deuterium exchange coupled t...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD019530 | Pride
Nuclear receptor Vdr-rxr Xl-ms Hdx-ms 
ProteomicsHDX-MS of VDR-RXR in complex with ZK168281
Characterization of the interaction between the full nuclear receptor VDR-RXR heterodimer and VDR antagonist ZK168281
ORGANISM(S): Homo sapiens (Human) 
2020-12-16 | PXD019810 | Pride
Hdx-ms Nuclear receptors Antagonist 
GenomicsCorepressors (NCoR and SMRT) as well as Coactivators are Recruited to Positively Regulated 1α,25-Dihydroxyvitamin D3-Responsive Genes
Transcription factors require coactivators and corepressors to modulate transcription in mammalian cells. The vitamin D receptor (VDR) utilizes coactivators and corepressors to gain tight control over the activity of a diverse set of genes that can regulate calcium transport, slow proliferation and...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-39277 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of genes regulated by RXR and its partners in monocyte-derived dendritic cells
CD14+ human monocytes differentiating into DCs in the presence of IL4 and GM-CSF were treated with agonists for RXR and its partners or vehicle 18 hours after plating (experiment with RXR and permissive partners, donor 1-3) or 14 hours after plating (experiment with nonpermissive partners, donor 4-6...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-23073 | biostudies-arrayexpress
UnknownAgonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding.
Not available
S-EPMC9943875 | biostudies-literature
UnknownStructure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA.
Not available
S-EPMC3261568 | biostudies-literature
UnknownMolecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer.
Not available
S-EPMC7641746 | biostudies-literature
UnknownGenome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone.
Not available
S-EPMC2901394 | biostudies-literature
GenomicsThe Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D3 Hormone [ChIP-seq]
Osteocytes are derived from osteoblast lineage cells that become progressively embedded in mineralized bone. Development of the osteocytogenic cell line IDG-SW3 has enabled a temporal and mechanistic investigation of this process. Through RNA-seq analyses, we show that while substantial changes in...
ORGANISM(S): Mus musculus 
2014-05-30 | E-GEOD-54782 | biostudies-arrayexpress
UnknownVDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.
Not available
S-EPMC3248320 | biostudies-literature
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