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ProteomicsLongitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.
Background: Non-human primates, such as Rhesus macaques, are a powerful model for studies of the cellular and physiological effects of radiation, development of radiation biodosimetry, and for understanding the impact of radiation on human health. Here, we study the effects of 4 Gy total body irradi...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2023-05-10 | PXD037807 | Pride
Radiation Biomarkers 
TranscriptomicsIMR90 4hr bystander experiment 0.5Gy alpha particle strip dish format
Radiation affects tissue and cellular integrity at the level of DNA, protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and tissue and radiation induced bystander effects are significant to exposed individuals in accidental or ...
ORGANISM(S): Homo sapiens 
2008-12-28 | E-GEOD-12435 | biostudies-arrayexpress
TranscriptomicsIMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the contribution of genome level changes in neighboring bystander cells to tissue and organ stress after irradiation. The timing of these ...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21059 | biostudies-arrayexpress
TranscriptomicsIMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. It raises concerns for the interpretation of risks from exposure to low doses of ionizing radiation. Sparse data exists about the bystander signaling mechanisms...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-18760 | biostudies-arrayexpress
TranscriptomicsRadiation-induced bystander effects and gene expression in cells deficient for RAD9
Background: The radiation bystander response is an important component of the overall response of cells to radiation and critical to understanding health risks of radiation exposure to humans. The mechanism of radiation response includes inter-cellular signaling and intra-cellular communication by w...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-55869 | biostudies-arrayexpress
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