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ProteomicsCarbonic anhydrases, EPF2 peptide and a novel protease, CRSP, mediate CO2 control of stomatal development
Environmental stimuli, including elevated CO2, regulate stomatal development1-3 but the key mechanisms mediating the perception and relay of the CO2 signal to the stomatal development machinery remain elusive. To adapt CO2 intake to water loss, plants regulate the development of stomatal gas exchang...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2014-08-22 | PXD000956 | Pride
Protease Stomata Arabidopsis 
ProteomicsObscurin and Obsl1 functions for “Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”
“Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013008 | Pride
Obscurin Obsl1 Sarcoplasmic reticulum organization Muscle metabolism Sarcolemmal integrity 
ProteomicsCancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis
Metabolic reprogramming of non-cancer cells residing in a tumor microenvironment, as a result of the adaptations to cancer-derived metabolic and non-metabolic factors, is an emerging aspect of cancer-host interaction. We show that in normal and cancer-associated fibroblasts, breast-cancer-secreted e...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-24 | PXD022311 | Pride
Mouse Mass spec Silac 
ProteomicsDigestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients
Heart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence in acute multiorgan failure suggests that active digestive enzymes leak out of the small intestine into the systemic circulation and cause ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD026332 | Pride
Heart failure Free peptides Digestive enzymes Proteomics 
ProteomicsCombined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
Background: Muscle proteins of the obscurin protein family play important roles in sarcomere organization, sarcoplasmic reticulum (SR) and T-tubule architecture and function. However, their precise molecular functions and redundancies between protein family members as well as their involvement in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058697 | Pride
Mouse heart muscle itraq obscurin 
ProteomicsA novel protein extraction method for proteomics of the trunk disease fungus Lasiodiplodia theobromae (Botryosphaeriaceae)
Fungal proteomics is a developing field that requires renewed interest and attention from the scientific community in many aspects. One of the most compelling objectives of fungal biology is to find out how fungal pathogens colonize a host, in order to find new ways of impeding this colonization, an...
ORGANISM(S): Lasiodiplodia theobromae 
2017-04-05 | PXD005283 | Pride
De novo peptide sequencing Proteomics Lc-nanoesi-ms Gene ontology Trunk-disease fungi 
ProteomicsEvolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates
PDZ domains are one of the most abundant protein domains in eukaryotes and frequently found on junction-localized scaffold proteins. Various signaling molecules bind to PDZ proteins via PDZ-binding motifs (PBM) and finetune cellular signaling. Here we describe the presence of a PBM on GIV/Girdin (CC...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022601 | Pride
Lc-msms Cancer Human 
ProteomicsMulti-omic analysis of meningeal cerebral amyloid angiopathy reveals enrichment of specific proteins and heparan sulfate disaccharides
Cerebral amyloid angiopathy (CAA) is a common feature of Alzheimer’s disease in which amyloid-β (Aβ) deposits in cerebral and leptomeningeal vessel walls, predisposing to micro- and macro-hemorrhage. The vessel wall has distinct proteins and heparan sulfate (HS), linear polysaccharides that bind Aβ ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056864 | Pride
Human amyloid meningeal proteomics 
ProteomicsAllergen Shedding in Human Milk from Mothers of Preterm Infants: Proteomic and Peptidomic Feasibility and Pilot Analysis
There is little information regarding the allergen content of milk feeds in the preterm population. Previous studies have evaluated specific proteins/peptides via ELISA, but no studies have performed a broad analysis of the allergenic peptide content and protease activity of milk feeds in this popul...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-01-26 | PXD033473 | Pride
Human Allergen Native paptides Milk 
ProteomicsCancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote muscle proteolysis
Decline in skeletal muscle mass and lower muscular strength are prognostic factors in advanced human cancers. We found that breast cancer suppressed O-linked N-acetylglucosamine (O-GlcNAc) protein modification in skeletal muscle through extracellular-vesicle-encapsulated miR-122 that targeted O-GlcN...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD021232 | Pride
Mouse cancer glycosylation 
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