Sort   by:  
 Page size 
ProteomicsNeutrophil extracellular traps melt Peyer’s patches following stroke and myocardial infarction
Sterile tissue injury after stroke causes lymphocyte contraction in lymphoid tissues and may decrease circulating IgA-levels. Intestinal Peyer’s patches (PP) harbor large numbers of IgA+ B cell precursors and plasma cells. Whether and how tissue injury triggers PP-B cell death, thereby mediating IgA...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-28 | PXD044644 | Pride
Stroke Neutrophil extracellular traps Immunosuppression Lymphocytes Myocardial infarction Peyer’s patches 
ProteomicsGut microbiota induce neutrophil activation that aggravates stroke pathology
Neutrophils, key players in the innate immune system, become activated following ischemic stroke. However, the influence of gut microbiota on neutrophil activation and its impact on inflammatory brain injury is not yet fully understood. In this study, we demonstrate that microbiota colonization in g...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD060229 | Pride
Gut microbiota Proteomics Stroke Neutrophil 
ProteomicsCD177 deficiency defines a stable subtype of human neutrophil granulocytes
CD177 is a surface protein on human neutrophil granulocytes whose function is related, but not limited to, tissue infiltration. While a fraction of the population is completely CD177-deficient (CD177d), most individuals express CD177. Expression levels on cells are not uniform and in every individua...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD068607 | Pride
Human neutrophils Proteomics Circulation Inflammation Lfq Cd177 
ProteomicsProteomic characterization of 1,000 human and murine neutrophils freshly isolated from blood and sites of sterile inflammation
Neutrophils, crucial player in inflammation, present a significant challenge in comprehensive molecular characterization due to limited availability (~1,000 cells) in inflamed sites like steady state infiltration. Prior proteomic studies typically required millions of neutrophils, posing difficultie...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-10-11 | PXD050682 | Pride
Proteomics Inflammation Stroke Low input Dia pasef Transmigration Neutrophil 
ProteomicsTargeted validation of significantly altered semen proteins in COVID-19 patients
The current global outbreak of COVID-19 has significantly impacted several organ systems. Male reproductive organs are among the potential targets of SARS-CoV-2 infection owing to the presence of abundant viral receptors; ACE2 and TMPRSS2 in the testis. However, the questions pertaining to the long...
ORGANISM(S): Homo Sapiens 
2022-06-26 | PXD026849 | panorama
Sort   by:  
 Page size