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TranscriptomicsTranscription profiling of human FoxP3+CD4+CD25+high regulatory T cells (Tregs) isolated from recent-onset type 1 diabetes mellitus (T1D) patients and controls
Naturally occurring FoxP3+CD4+CD25+high regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing auto-reactive CD4+CD25- T cell activity. Although Tregs from T1D subjects are functionally deficient, there is little knowledge of the molecular mechanisms that orchestrate th...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10586 | biostudies-arrayexpress
TranscriptomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]
Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using microarray. Expression profiling by microarray of Treg cells treated with DMSO or CBP inhibitor, and Th0 cells
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-66596 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse D10.G4.1 T-cells treated with neuromedin U for different length of time to study the effect of neuromedin on gene expression in T cells.
Effects of Neuromedin-U on gene expression in mouse D10.G4.1 T-cells natively expressing the GPCR Axor13
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-1791 | biostudies-arrayexpress
TranscriptomicsChemical Inhibition of the ROR?t-dependent Transcriptional Network in Th17 cells [RNA-Seq]
ROR?t is a transcription factor required for T helper 17 (Th17) cell development. We identified three ROR?t-specific inhibitors that suppress Th17 cell responses including Th17 cell-mediated autoimmune disease. We systemically characterized ROR?t binding data in the presence and absence of drug with...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56018 | biostudies-arrayexpress
ProteomicsIdentification of naturally-presented influenza A virus CD8+ T cell epitopes
Influenza viruses (IV) infection is a public health concern worldwide. Currently, all available vaccines as well as antiviral drugs that target the virus itself are prone to resistance. Lessons learned from previous pandemic outbreaks is that people with a preexisting cellular immune response are ei...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD035241 | Pride
Influenza a virus Ligandome analysis Cd8+ t cell T cell epitopes 
ProteomicsDifferentially expressed proteins in Human Primary Keratinocytes upon IL-9 stimulation
HPKs from 3-5 healthy individual donors were pre-stimulated with TGFb (10ng/ml) plus IL-4 (20ng/ml) to upregulated the IL-9R (Das et al., 2019). Next day, HPKs were stimulated with IL-9 (50ng/ml) or in combination with IFNg (10ng/ml) for 24 hours at 37 degree C with 5% CO2. Sample preparation for L...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-28 | MSV000086776 | MassIVE
TranscriptomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [RNA-seq]
Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using RNA sequencing (RNA-seq). Expression profiling by RNA-seq of Treg cells treated with DMSO or CBP inhibitor
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-70620 | biostudies-arrayexpress
UnknownT regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.
Not available
S-EPMC2996054 | biostudies-literature
ProteomicsDynamic of the Grb2 interactome in primary cells by DDA-MS
We applied AP-MS to quantify Grb2 interaction dynamics in primary T cells. Data generated here in shotgun/DDA mode were used to build a high quality Grb2 binders-specific SWATH assay library for high-throughput targeted analysis of DIA data.
ORGANISM(S): Mus musculus (Mouse) 
2017-03-09 | PXD003973 | Pride
Primary t cells Ms Grb2 Interactome Dda 
GenomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [ChIP-seq]
Genome-wide chromatin H3K27ac, H3K18ac and H3K4me3 occupancy changes in response to CBP inhibitor treatment in Treg cells using ChIP sequencing (ChIP-seq). Expression profiling by ChIP-seq of Treg cells treated with DMSO or CBP inhibitor
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-70708 | biostudies-arrayexpress
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