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ProteomicsGrb2 interactome data with and without EGF stimulation
Growth factor receptor-bound protein 2 or Grb2 is an adaptor protein involved in signal transduction. It is widely expressed and integral to several cellular functions, including cell proliferation. We designed this study to capture interacting partners of Grb2 in absence and presence of epidermal g...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD012957 | Pride
Ap-ms Silac Interactome Grb2 Egf 
TranscriptomicsMiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line
The biological significance of the down-regulation of miR-376c in HuCCT1 cells is unknown. We revealed that miR-376c significantly reduced EGF-dependent cell migration through its target GRB2 in HuCCT1 cells. To elucidate key molecules in EGF-dependent HuCCT1 migration, in which GRB2 upregulation is...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-47186 | biostudies-arrayexpress
GenomicsLoss of GRB2 results in nonreceptive endometrium and female infertility.
Loss of GRB2 results in nonreceptive endometrium and female infertility.
PRJNA1081904 | ENA
GenomicsComparison of E14.5 embryonic kidney transcriptomes (Grb2 ureteric-specific knockout vs wild-type)
Comparison of E14.5 embryonic kidney transcriptomes (Grb2 ureteric-specific knockout vs wild-type)
PRJNA684494 | ENA
ProteomicsDynamic of the Grb2 interactome in primary cells by DDA-MS
We applied AP-MS to quantify Grb2 interaction dynamics in primary T cells. Data generated here in shotgun/DDA mode were used to build a high quality Grb2 binders-specific SWATH assay library for high-throughput targeted analysis of DIA data.
ORGANISM(S): Mus musculus (Mouse) 
2017-03-09 | PXD003973 | Pride
Primary t cells Ms Grb2 Interactome Dda 
TranscriptomicsComparison of E14.5 embryonic kidney transcriptomes (Grb2 ureteric-specific knockout vs wild-type)
Grb2 is a small SH2-SH3 adaptor molecule that interacts with activated tyrosine kinase receptors (RTKs), providing a crucial link towards downstream activation of pro-proliferative and pro-survival ERK and Akt signaling pathways. Ret and FGFR2, two RTKs that interact with Grb2, play important roles ...
ORGANISM(S): Mus musculus 
2023-12-01 | GSE163040 | GEO
ProteomicsMapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway
The propagation of intracellular T cell receptor (TCR) signals involved various adapter proteins that are important molecular switches to connect proteins together. The global characterization of changes in protein-protein interactions following genetic perturbations is critical to understand the re...
ORGANISM(S): Homo sapiens (Human) 
2023-03-13 | PXD038891 | Pride
Ap-ms T cell Slp76 Grb2-family adaptors 
TranscriptomicsLoss of GRB2 results in nonreceptive endometrium and female infertility.
To understand the role of GRB2 in the uterus, we generated mice with conditional ablation of Grb2 in the PGR positive cells (Pgrcre/+Grb2f/f; Grb2d/d). Grb2d/d mice are infertile due to implantation failure. Although ovarian functions are normal, Grb2d/d mice had non-receptive endometrium due to dys...
ORGANISM(S): Mus musculus 
2025-01-07 | GSE260505 | GEO
Genomics
Grb2 regulation of miRNA expression
PRJNA725410 | ENA
ModelsCapuani2015 - Binding of Cbl and Grb2 to EGFR (Early Activation Model - EAM)
Fabrizio Capuani, Alexia Conte, Elisabetta Argenzio, Luca Marchetti, Corrado Priami, Simona Polo, Pier Paolo Di Fiore, Sara Sigismund & Andrea Ciliberto. Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells. Nature Communications 6 (2015)...
2024-09-02 | BIOMD0000000595 | BioModels
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